The University of Mississippi

R.p.scherer Technologies, Inc.

Kashiv Biosciences, LLC

Roshan Vijay Tiwari

Michael Andrew Repka

Jun-Bom Park

Hemlata Gunga Patil

Joseph Thomas Morott, Jr

Wenli Lu

Sampada Bhaskar Upadhye

Ronald S Vladyka

Navnit Hargovindas Shah

Wantanee Phuapradit

Dipen Desai

Siva Ram Kiran Vaka

Harpreet Kaur Sandhu

Atsawin Thongsukmak

Ronald S Vladyka, Rph

Chanchal Patel

Joseph Thomas Morott

A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Twin-screw dry granulation for producing solid formulations

The presently disclosed subject matter provides a solid, immediate release, pharmaceutical multi-particulate dosage form containing at least one population of Opioid Particulates comprising one or more opioids; at least one population of Naloxone Particulates; and a population of Triggering Particulates. Each population of particulates is designed for a specific function to accomplish the desired combination of abuse deterrence and overdose protection.

Opioid agonist / antagonist combination dosage forms

Growing community of inventors

Hillsborough, NJ, United States of America

Roshan Vijay Tiwari