Council of Scientific and Industrial Research

Roshan Rajan Kulkarni

Swati Pramod Joshi

Dhiman Sarkar

Ketaki Dilip Shurpali

Sampa Sarkar

Upasana Singh

The present invention describes the use of pharmaceutical compositions including compounds of formula 2 (below) for treatment of infections related toand for anti-proliferative activity. Also, the present invention discloses a process of extraction of compounds of formula 2 from the extract of aerial parts of: 

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This invention relates to diterpenes of general formula (1) belonging to labdane class, isolated from, being useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further discloses process for isolation of the fractions containing the same. 

C-9 oxygen functionalized labdane derivates

Active fractions exhibiting anti-tuberculous activity from the plant(family&#x2014;Sterculiaceae) are described. Methanol extracts of the aerial part ofexhibited activity against MtbGS in primary screening of biosynthetic assay. Subsequent fractionation was carried out in organic solvents. Out of all these, two fractions (fraction D and K) are exhibiting inhibitory activity againstglutamine synthetase activity. These fractions D and K are inhibiting 74% and 44% respectively at 7.5 mg/ml concentrations. The determined ICvalue of the fraction K is found to be 4.5 mg/ml from the dose response curve against the purifiedGlutamine Synthetase. The ICvalue forBCG is 1.56 &#x3bc;g/ml. It was observed that there was no significant effect on proliferation of HL-60 cell line at 10&#xd7;MIC levels of the hits. This data indicated that these compounds could be initially considered to be safe.

This invention discloses diterpenes class of novel compounds of general formula I from a novel source. More particularly the invention relates to extracts/fractions containing pimarane diterpenes from(Lamiaceae), useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further relates to extracts, fractions standardized to diterpenes class of novel compounds useful for the treatment of cancers.

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Maharashtra, India

Roshan Rajan Kulkarni