Icos Corporation

Other

Rosemay Vazeux

W Michael Gallatin

DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated &ldquo;ICAM-R&rdquo;) and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Antibodies substances specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding reactions involving ICAM-R.

I-CAM related protein

DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated 'ICAM-R') and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.

ICAM-related protein

Fusion proteins comprising ICAM-R polypeptides and immunoglobulin

Antibody substances that bind to a novel human intercellular adhesion molecule polypeptide (designated 'ICAM-R') and variants thereof are disclosed along with methods and materials producing and screening the same for desired functional and binding properties. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.

Antibody substances that bind to ICAM-related protein

DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated 'ICAM-R') and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Antibodies and other binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R.

Antibodies to ICAM-related protein

Modulators of protein kinase C phosphorylation of human intercellular adhesion molecule polypeptide (designated 'ICAM-R') are identified through novel methods.

Methods for identifying modulators of protein kinase C phosphorylation

DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated 'ICAM-R') and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R. Specifically, antibody substances which modulate the interaction between ICAM-R and ad/CD18 are provided.

Modulators of the interaction between ICAM-R and .alpha..sub.d /CD18

Methods for monitoring the progression of systemic lupus erythematosus (SLE) in a patient by detecting elevated levels of circulating ICAM-R wherein progression is indicated in an SLE patient whose circulating ICAM-R levels are increased as compared to normal individuals or individuals with in active SLE. Methods for the detection of an inflammatory disease state selected from the group consisting of rheumatoid arthritis, SLE, and Guillain-Barre syndrome and multiple sclerosis in a patient by detecting elevated levels of circulating ICAM-R wherein the presence of the inflammatory disease state is indicated in a patient whose circulating ICAM-R levels are increased as compared to normal healthy individuals. ICAM-R is also known as ICAM-3 and CDw50 in the art.

Method for monitoring an inflammatory disease state by detecting

DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated 'ICAM-R') and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding biological activities of ICAM-R. More specifically, humanized antibodies specific for ICAM-R proteins are disclosed.

Humanized antibodies specific for ICAM related protein

ICAM-related protein variants

Method to identify compounds which modulate ICAM-related protein

ICAM-related protein fragments

DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated 'ICAM-R') and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Antibodies substances specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the modulation of ligand/receptor binding reactions involving ICAM-R.

Assay for 1-CAM related protein expression

DNA sequences encoding a novel human intercellular adhesion molecule polypeptide (designated 'ICAM-R') and variants thereof are disclosed along with methods and materials for production of the same by recombinant procedures. Antibodies substances specific for ICAM-R and variants thereof are also disclosed as useful in both the isolation of ICAM-R from natural cellular sources and the inhibition of ligand/receptor binding reactions involving ICAM-R.

Growing community of inventors

Seattle, WA, United States of America

Rosemay Vazeux