Cellzome Limited

Aqdot Limited

Cellzone Limited

Rosemary Lynch

Rita Adrego

Andrew David Cansfield

Daniel Paul Hardy

Nigel Ramsden

Mihiro Sunose

Adeline Morel

Laura Convery

Alison Jones

Jeremy Major

Richard John Harrison

Helen Sarah Niblock

John Thomas Feutrill

Roger Coulston

Jane Elizabeth Scanlon

David Diec

Matthew Rowland

Tammy Ladduwahetty

Ben Cheesman

Jessica Taylor

Katie Ellard

Epoxy compositions include a cucurbituril in complex with a curative, and methods for curing the epoxy composition. The curative is reactive with an epoxy compound, and the curative may be a cure accelerator or a cure hardener. Cured resins are obtained or obtainable from the epoxy compositions. Complexes of a cucurbituril have a curative.

Curing compositions

The present invention relates to compounds of formula (I) wherein R, R, Xto Xhave the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

Heterocyclyl pyrimidine analogues as TYK2 inhibitors

The invention relates to compounds of formula (I) wherein X, X, Rto R, m, and n have the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including the compounds, the preparation of such compounds as well as the use as medicaments.

Morpholino substituted urea derivatives as mTOR inhibitors

The invention relates to compounds of formula (I) wherein m, o, R, R, Rand Thave the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including the compounds, the preparation of the compounds as well as their use as medicaments.

Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors

The invention relates to compounds of formula (I) wherein m, n, R, Tand Thave the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds as well as methods of treating mTOR related diseases.

Morpholino substituted urea or carbamate derivatives as MTOR inhibitors

The invention relates to compounds of formula (I) wherein X, R, R, T, m, n, o have the meaning as cited in the description and the claims. The compounds of formula (I) are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

Pyrimidine derivatives as mTOR inhibitors

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Cambridge, United Kingdom

Rosemary Lynch