The Procter Gamble Company

The Proctor 'Gamble Company

Rosemarie Osborne

Lisa Ann Mullins

Michael Koganov

Deborah Ruth Finlay

Robert Scott Youngquist

Jun Xu

Jeffrey David Edwards

Robert Lloyd Binder

Kenton Duane Juhlin

Scott Michael Hartman

Matthew James Mcildowie

Donald Lynn Bissett

Larry Richard Robinson

Charles Carson Bascom

Makio Tamura

Deborah Ruth Finley

Heather Lynn Rocchetta

Cheri Lynn Millikin

Michael Keith Robinson

Laura Jackson Goodman

Deirdre Anne Roberts

Mary Ann Perkins

Gregory Joseph Kramer

Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.

Anti-aging skin care compositions and regimens

A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.

Method of making skin care compositions

A method of improving the appearance of aging skin that includes applying an effective amount of artichoke leaf extract and vitamin Bcompound in combination to a target area of skin that exhibits a sign of aging skin, and compositions that include an effective amount of artichoke leaf extract and vitamin Bcompound in combination. The composition is applied for a period of time sufficient for the combination of vitamin Bcompound and niacinamide to improve the appearance of the aging skin.

Method of improving the appearance of aging skin

Personal care compositions that include bioactive ingredients derived from achachairu and methods of making the same. The bioactive compositions (ingredients) of the present invention may be free of or substantially free of benzophenones and/or protein, and may exhibit anti-inflammatory, anti-oxidant, anti-aging, and/or anti-protein loss properties. The achachairu ingredient may be in the form of a serum fraction and/or an extract. The personal care compositions are formulated for topical use on skin and/or hair.

Personal care composition and method of making the same

Topical skin care compositions that include bioactive ingredients derived from achachairu and methods of making the same. The bioactive compositions (ingredients) of the present invention may be free of or substantially free of benzophenones and/or protein, and may exhibit anti-inflammatory, anti-oxidant, and/or anti-aging properties. The achachairu ingredient may be in the form of a serum fraction and/or an extract.

Skin care composition and method of making the same

A method of regulating a skin conditions that includes applying a safe and effective amount ofto a target portion of skin in need of treatment or where treatment is desired. Thecan be in the form of a bioactive ingredient that exhibits anti-inflammatory, anti-oxidant, and/or anti-aging properties, and which is free or substantially free of benzophenones and/or protein. Theingredient may be a serum fraction and/or an extract, and may be incorporated into a skin care composition formulated for topical use on skin.

Method of regulating a skin condition

A method of regulating mammalian keratinous tissue that includes applying a safe and effective amount of achachariu to a target portion of keratinous tissue. The achachariu can be in the form of a bioactive ingredient that exhibits anti-inflammatory, anti-oxidant, anti-aging, and/or anti-protein loss properties, and which is free or substantially free of benzophenones and/or protein. The achachariu ingredient may be a serum fraction and/or an extract, and may be incorporated into a personal care composition formulated for topical use on skin and/or hair.

Method of regulating a condition of mammalian keratinous tissue

Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.

Personal care compositions

A method of making a skin care product that includes a skin care composition containing a skin care active with a diamagnetic susceptibility of between about &#x2212;400 and &#x2212;600, constructing an applicator for applying the skin care composition to a target portion of skin, and packaging the composition and applicator for retail sale. The applicator includes a magnetic array tailored to enhance penetration of the skin care active into skin. The magnetic array may be unidirectional magnetic array or a bi-directional magnetic array.

Method of making a skin care product

A cosmetic skin care product that includes an applicator and a skin care composition. The applicator includes a uni-directional magnetic array with a pitch of between 1.7 and 2.5 and a magnetic field strength of between about 24.0 and 36.0 mT. The skin care composition includes palmitoyl-lysine-threonine-threonine-lysine-serine and a dermatologically acceptable carrier. The magnetic array is tailored to enhance penetration of the Pal-KTTKS into skin during application of the skin care composition. The applicator may include a second magnetic array juxtaposed on a first magnetic array to form a bi-directional array that enhances penetration of the Pal-KTTKS into skin.

Skin care product and method of use

A cosmetic skin care composition for improving the appearance of aging skin. The composition is topically applied to a target area of skin where treatment is desired. The composition includes an effective amount of artichoke leaf extract and carob fruit extract in combination, and is applied for a period of time sufficient to improve the appearance of the aging skin.

Compositions for improving the appearance of aging skin

A stable skin care composition for improving the appearance of aging skin is disclosed. The stable skin care composition that includes an effective amount of artichoke leaf extract and carob fruit extract that, in combination, can provide a synergistic increase in the up-regulation of key epidermal-associated genes related to skin aging, and thereby provide an improvement in the appearance of aging skin. The stable skin care composition excludes complexing agents and includes sunscreen agents to help photostablize the composition.

A screening method for identifying an agent as effective for providing an anti-aging skin benefit is provided. The screening method includes culturing first and second human skin samples from about 3 days to about 19 days, wherein the first and second human skin samples are derived from a human skin surgical waste tissue. The first human skin sample is contacted with at least one test agent. The second human skin sample is contacted with a positive control. Transcriptional profiles are generated from the first and second human skin samples, and the at least one test agent is identified as effective for providing an anti-aging skin benefit when the transcriptional profiles of at least two genes show a similar directional change in comparison to one or more untreated control tissue samples.

Growing community of inventors

Oxford, OH, United States of America

Rosemarie Osborne