Merck + Co., Inc.

Rutgers, the State University of New Jersey

Merck Sharp + Dohme Corp.

University of Medicine and Dentistry of New Jersey

Rosemarie Kelly

Kathrin Ute Jansen

Annaliesa Sybil Anderson

Jennifer Nielsen Kahn

Cameron M Douglas

David S Perlin

Steven Park

Stephen A Parent

Elizabeth A Register

Janet C Onishi

Loren D Schultz

John R Thompson

Prakash S Masurekar

Tessie Brown McNeely

Donna Lorraine Montgomery

Nancy R Morin

Mohammed El-Sherbeini

Myra B Kurtz

Gary L Chrebet

Joseph A Clemas

Forrest Foor

Mark Andrew Miller

Stephen Authur Parent

Gan-Ju Maria Shei

Mark D Yeager

Naasa M Ramadan

Jean A Marrinan

Tessie Mcneely

Mark A Miller

William L Mcclements

Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.

Assays for resistance to echinocandin-class drugs

The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof,AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full lengthAhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against. 

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There is disclosed a procedure for DNA-mediated transformation of Candida albicans by electroporation utilizing lithium acetate and dithiothreitol to weaken the cell wall structure and optimize the yield of transformants.

Transformation of Candida albicans by electroporation

DNA encoding 1,3 beta-D glucan synthase subunits

There is disclosed an isolated gene coding for an enzyme involved in proline biosynthesis in Zalerion arboricola. There is also disclosed a method of using the gene to produce a strain of Z. arboricola containing high titers of a desirable fermentation product.

P5C reductase gene from zalerion arboricloa

Growing community of inventors

Westfield, NJ, United States of America

Rosemarie Kelly