Dana-Farber-Cancer Institute Inc.

Leland Stanford Junior University

Harvard College

Children's Medical Center Corporation

The Brigham and Women's Hospital, Inc.

Children's Hospital

Boston Children's Hospital

Children's Hospital Boston

Rosemarie Dekruyff

Gordon James Freeman

Dale T Umetsu

Yanping Xiao

Arlene Helen Sharpe

Jennifer L Jones

Susan Knox

Everett Hurteau Meyer

Loise M Francisco

Jennifer Jones McIntire

Panagiota Iliopoulou

Yuchiao Hsu

Vijay K Kuchroo

Magdiel Pérez Cruz

Magdiel Perez Cruz

Sanhong Yu

Arlene H Sharpe

The present invention relates to compositions and methods for the modulation RGMb-Neogenin-BMP signaling.

Agents that modulate RGMb-neogenin-BMP signaling and methods of use thereof

The present invention relates to compositions and methods for the immunomodulation mediated by the interaction of PD-L2 and RGMb.

Agents that modulate immune cell activation and methods of use thereof

RGMb antagonists reduce undesirable immune responses associated with tissue or organ transplantation.

Blockade of RGMB for reducing transplantation-associated inflammation leading to loss of function of a transplanted organ in a graft recipient

Blockade of RGMb for reducing transplantation-associated immune responses

A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.

Modulation of TIM receptor activity in combination with cytoreductive therapy

A genetic locus and corresponding family of proteins associated with regulation of immune development, function, and cell survival are provided. The locus comprising the TIM family is genetically associated with immune dysfunction, including atopy, autoimmunity, inflammatory bowel disease, dysplasia, and susceptibility to blood-bourne infectious diseases. Polymorphisms in the human TIM-1 gene and exposure to Hepatitis A Virus (HAV) are shown to be associated with protection from the development of atopy.

T cell regulatory genes associated with immune disease

T cell regulatory genes and methods of use thereof

Growing community of inventors

Portola Valley, CA, United States of America

Rosemarie Dekruyff