Chiesi Farmaceutici S.p.a.

Vectura Gmbh

Rosella Musa

John Nicholas Staniforth

David Alexander Vodden Morton

Daniela Cocconi

David Morton

Roberto Bilzi

Angela Armanni

Roberto Rastelli

The invention provides a formulation to be administered as dry powder for inhalation suitable for efficacious delivery of low-dosage strength active ingredients to the low respiratory tract of patient. In particular, the invention provides a formulation comprising microparticles constituted of microparticles of a low-dosage strength active ingredient and microparticles of an excipient wherein the MMD of the microparticles is comprised between 2 and 15 micron, at least 10% of the microparticles has a mass diameter (MD) higher than 0.5 micron, and the process of preparation thereof.

Pharmaceutical formulations for dry powder inhalers comprising a low-dosage strength active ingredient

A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.

Method of making particles for use in a pharmaceutical composition

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Parma, Italy

Rosella Musa