L'oreal

Societe Anonyme Dite: L'oreal

Rose-Marie J Handjani

Alain J Ribier

Guy G Vanlerberghe

Jacqueline Griat

Arlette Zabotto

Jean-Thierry Simonnet

Nadia Terren

Myriam Kauffmann

Pascal Richart

Frederic Huguenin

Henri Sebag

Christos Papantoniou

Alexandre Zysman

Manlio M Maurelli

Alian J Ribier

Composition comprising biodegradable nanoparticles encapsulating oils which are active and/or which contain an active ingredient having a cosmetic and/or pharmaceutical action in the upper layers of the epidermis. The nanoparticles are preferably prepared from a polymer of (C,-C,) alkyl cyanoacrylate.

Composition for the cosmetic and/or pharmaceutical treatment of the upper layers of the epidermis by topical application to the skin, and corresponding preparation process

Composition providing a lasting cosmetic and/or pharmaceutical treatment

The vesicles are prepared from a lipid phase containing a mixture of nonionic amphiphilic lipids consisting of a mixture of esters of at least one polyol chosen from the group composed of polyethylene glycol containing from 1 to 60 ethylene oxide units, sorbitan, sorbitan bearing 2 to 60 ethylene oxide units, glycerol bearing 2 to 30 ethylene oxide units, polyglycerols containing 2 to 15 glycerol units, sucroses, and glucoses bearing 2 to 30 ethylene oxide units and of at least one fatty acid containing a saturated or unsaturated, linear or branched C.sub.5 -C.sub.17 alkyl chain, the number of alkyl chains per polyol group being between 1 and 10, the mixture being stabilized with ionic amphiphilic lipid or lipids chosen from the group composed of those which impart a pH of between 5.5 and 7.5 to the dispersion.

Composition composed of an aqueous dispersion of stabilized vesicles of

A composition containing, in a suitable carrier, nanoparticles of one or more nonbiodegradable polymer(s) encapsulating an oily phase which contains at least one active oil and/or at least one carrier oil and/or at least one active ingredient in an active oil and/or a carrier oil. At least one active ingredient is chosen from those with prolonged cosmetic and/or pharmaceutical activity. The nanocapsules have a size of 100-1000 nm.

A cosmetic composition which is a dispersion of spheres in an external aqueous phase. The spheres are organized molecular layers of a nonionic lipid material encapsulating an internal aqueous phase. The external aqueous phase contains an oil.

Cosmetic composition based on an aqueous dispersion of small lipid

A cosmetic composition which is a stabilized, oil-in-water dispersion of spheres in an external aqueous phase. The spheres are organized molecular layers of a nonionic amphiphilic lipid material encapsulating an internal aqueous phase. The external aqueous phase, containing an oil, is free of any surface active emulsifying agent.

Composition for promoting healing containing, as a healing agent, nonionic vesicles obtained from a lipid mixture containing at least one nonionic lipid having the formula; ##STR1## wherein R is either at least one C.sub.16 -C.sub.18 radical, or R'CO wherein R' is at least one C.sub.15 -C.sub.17 alkyl radical, in combination with cholesterol and, optionally, dicetylphosphate or tetracetylphospate. This composition can be used topically to accelerate the scarring of wounds.

Composition for promoting healing

A process for producing alginate capsules comprises slowly introducing an aqueous alginate solution into crosslinking solution of a polyvalent metal salt. The aqueous alginate solution has mannuronic units (M) and guluronic units (G) in a molar ratio between 0.4 and 1.9 and preferably an amount of (G) blocks greater than 50%. Preferably, the alginate is a sodium alginate having a viscosity, in a 0.5% solution in water at 25.degree. C., lower than 20 mPa.s measured with a TV Contraves viscosimeter having a No. 1 measurement body in the presence of a calcium chelate. The alginate concentration is between 0.2 and 2 weight percent. The polyvalent metal salt concentration in solution is from 3.4.times.10.sup.-3 to 6.8.times.10.sup.-2 M. The alginate capsules are employed in cosmetic compositions.

Process for the preparation of alginate capsules, apparatus for

A process for the preparation of a stable emulsion of at least one water-immiscible liquid phase L in an aqueous phase D is described which comprises mixing the liquid phase or phases L with a dispersion of spheres in an aqueous phase D, the spheres having an average diameter of 0.025 to 5 microns and consisting of substantially concentric lipid laminae encapsulating an aqueous phase E between them, the lipid or lipids constituting the laminae being ionic or nonionic amphiphilic substances capable of forming a lamellar phase in water, and subjecting the whole to mechanical agitation so as to disperse the phase (or phases) L in the phase D in the form of droplets having an average diameter of 0.1 micron to a few microns.

Process for the preparation of stable dispersions of at least one

A process for producing alginate capsules comprises slowly introducing an aqueous alginate solution into crosslinking solution of a polyvalent metal salt. The aqueous alginate solution has mannuronic units (M) and guluronic units (G) in a molar ratio between 0.4 and 1.9 and preferably an amount of (G) blocks greater than 50%. Preferably, the alginate is a sodium alginate having a viscosity, in a 0.5% solution in water at 25.degree. C. lower than 20 mPa.s measured with a TV Contraves viscosimeter having a No. 1 measurement body in the presence of a calcium chelate. The alginate concentration is between 0.2 and 2 weight percent. The polyvalent metal salt concentration in solution is from 3.4.times.10.sup.-3 to 6.8.times.10.sup.-2 M. The alginate capsules are employed in cosmetic compositions.

A perfume composition, with an aqueous phase, having a high concentration of perfume, which contains: a) vesicles which are obtained from at least one non-ionic lipid derived from a linear or branched polyglycerol, associated with a stabilizer present in a proportion of 1 to 10% by weight based on the lipid, the vesicles having an average diameter of between 0.01 .mu. and 1 .mu. and the lipids which form the vesicles representing 0.2 to 4% by weight of the total composition; and b) a perfume in the form of droplets having an average diameter of between 0.1 .mu. and 1 .mu. and being present in the composition in amounts of between 3 and 20% by weight based on the total composition, the total ratio of the lipid or lipids of the vesicles to the perfume being between 0.05 and 0.2.

Perfume composition, with a continuous aqueous phase, having a high

A process for producing a dispersion of spherules of a lipid compound encapsulating an aqueous phase includes admixing a water-dispersible lipid compound with an aqueous phase to be encapsulated in the spherules, agitating the resulting mixture to form a lamellar phase, adding a liquid dispersion phase and vigorously shaking the resulting mixture.

Process for the production of aqueous dispersions of lipid spheres

A dispersion in a continuous phase or spherules comprises arranged molecular layers of a non-ionic lipid compound encapsulating an aqueous phase wherein the non-ionic lipid compound has a lipophile group/hydrophile group ratio such that the non-ionic lipid compound swells in the aqueous phase to be encapsulated therein so as to form a lamellar phase. The hydrophile group of the non-ionic compound is selected from the group consisting of polyoxyethylene groups, polyglycerol groups and esters of polyols. The spherules have a diameter between 1,000 .ANG. and 50,000 .ANG..

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Paris, France

Rose-Marie J Handjani