Epitech Group S.r.l.

Epitech Group S.p.a.

Rosaria Meli

Francesco Della Valle

Maria Federica Della Valle

Gabriele Marcolongo

Giuseppe D'Agostino

Roberto Russo

Antonio Calignano

Sonia Laneri

Carmine Ostacolo

Antonia Sacchi

Diana Tronino

Giuseppe D'agostino

The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues&#x2014;particularly in the skin and mucosae&#x2014;and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.

Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides

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Milan, Italy

Rosaria Meli