Massachusetts Institute of Technology

Rosalind Picard

Richard Glen Fletcher

Daniel J McDuff

Ming-Zher Poh

Hoda Eydgahi

Clayton Williams

Nancy Alice Tilbury

Kelly Elizabeth Dobson

Mohammed Ehasanul Hoque

Oliver Orion Wilder-Smith

Sarah Gontarek

Kyunghee Kim

Jackie Chia-Hsun Lee

Sarah Pratt

Jonathan Farringdon

Jocelyn C Scheirer

In illustrative implementations of this invention, a photoplethysmographic device measures variations of light that is reflected from, or transmitted through, human skin. In some implementations, the device includes a camera that takes the measurements remotely. In others, the device touches the skin during the measurements. The device includes a camera or other light sensor, which includes at least orange, green and cyan color channels. In some cases, such as a contact device, the device includes three or more colors of active light sources, including at least orange, green and cyan light sources. A computer analyzes the sensor data, in order to estimate a cardiac blood volume pulse wave. For each cardiac pulse, a computer detects the systolic peak and diastolic inflection of the wave, by calculating a second derivative of the wave. From the estimated wave, a computer estimates heart rate, heart rate variability and respiration rate.

Methods and apparatus for physiological measurement using color band photoplethysmographic sensor

In exemplary implementations of this invention, a display screen and speakers present an audiovisual display of an animated character to a human user during a conversational period of a coaching session. The virtual character asks questions, listens to the user, and engages in mirroring and backchanneling. A camera and microphone gather audiovisual data regarding behavior of the user. After the conversational period, the display screen and speakers display feedback to the user regarding the user's behavior. For example, the feedback may include a plot of the user's smiles over time, or information regarding prosody of the user's speech. The feedback may also include playing a video of the user that was recorded during the conversational period. The feedback may also include a timeline of the human user's behavior. The virtual coaching may be provided over the Internet.

Methods and apparatus for conversation coach

In exemplary implementations of this invention, sensor measurements are taken before, during and after an epileptiform seizure of a human. The sensors measure electrodermal activity (EDA) and heart rate variability (HRV) of the human. The EDA and HRV measurements are used to assess sympathetic activity and parasympathetic activity, respectively. More particularly, in the case of HRV measurements, HF power is used to assess parasympathetic innervation of the heart. HF power is the power of the high frequency (e.g. 0.15 to 0.4 Hz) spectral component of the RRI signal. One or more processors analyze the sensor data to calculate the magnitude of a post-ictal autonomic disturbance. Based on that calculated magnitude, the processors assess the severity of the seizure. A wrist-worn sensor may take long-term, continuous EDA and motion measurements. The processors may analyze these measurements to detect the onset of a tonic-clonic seizure.

Methods and apparatus for assessment of atypical brain activity

In an exemplary implementation of this invention, a user wears comfortable biosensors. These sensors gather physiological data from the user and transmit this data to another radio-enabled device. This other device may be a mobile phone. The data is further transmitted, via this other radio-enabled device, to one or more networks (such as wireless networks or the Internet). A processor analyzes this transmitted data, in real time, to recognize patterns in the data that indicate the need for therapeutic intervention. Upon recognition of such a pattern, the processor outputs instructions for a transducer to deliver therapeutic stimuli. These instructions are transmitted, over one or more wired or wireless networks, to a transducer which delivers the therapeutic stimuli to the user.

Methods and apparatus for monitoring patients and delivering therapeutic stimuli

A washable, wearable biosensor that can gather sensor data, communicate the sensed data by wireless protocols, and permits the analysis of sensed data in real-time as a person goes about their normal lifestyle activities. The biosensor can be worn in multiple positions, can be put on or removed quickly without having to apply or remove gels and adhesives, and provides a snug, comfortable fit to gather data with minimal motion artifacts. The textile, wearable device can support integrated photoplethysmography, skin conductance, motion, and temperature sensors in a small wearable package. The supported sensors may be coupled to utilization devices by channel-sharing wireless protocols to enable the transmission of data from multiple users and multiple sensors (e.g. both sides of body, wrists or hands and feet, or multiple people). An on-board processor, or the receiving utilization device, can map patterns of the physiological and motion data to signals or alerts such as a likely seizure, drug craving, or other states that the wearer may exhibit or experience. The sensor data may be sent by wireless transmission and received by a mobile phone or other personal digital device, a computer, a favorite toy, or another wearable device. The sensors may include multiple photoplethysmographs and/or one or more EDAs which perform a time-domain measurement of skin conductance.

Washable wearable biosensor

A skin-conductivity sensor is configured as a wearable device, such as an article of clothing worn on the hand but covering it only partially. The device may include an on-board power source and a source of illumination that provides a continuous visual indication of skin conductivity.

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Newton, MA, United States of America

Rosalind Picard