Biomerieux, Inc.

University of Sunderland

Rosaleen Joy Anderson

Paul William Groundwater

Arthur James

Daniel Monget

Andrey Victorovich Zaytsev

Sylvain Orenga

John Perry

Marie Cellier

Michael Dunn

Matthew Richard Benton

Ivan Hales

Neil Barnwell

Keng Tiong Ng

Lisa Frost

David Antony Phillip Small

Matthew Levick

Alexandre F Bedernjak

David Antony Philip Small

Linda Varadi

Yu Gong

Adam Todd

John D Perry

Linda VÁRADI

Methods are provided for the synthesis of a compound of formula (X). Ris selected from —H, —C-C-alkyl, —C-C-alkenyl and C-C-aryl; Ris selected from —C(O)H and —C(O)C-C-alkyl; and A is a pharmaceutically acceptable anion (e.g. a halide). Also provided are intermediate compounds formed during the synthesis.

Production processes of S- and O-diacylated gamma-glutamyl-cysteamine prodrugs

An antimicrobial compound, as well as the salts, derivatives and analogs thereof, said compound being represented by the general formula (I): wherein Rrepresents a peptide part P1 or a peptide part P2.

Antimicrobial compounds

The present subject matter relates generally to compounds having the formula (I): wherein each of X, Y, R, R, R, R, and n are as defined herein. Compounds of formula (I) may act as inhibitors of the thioredoxin reductase enzyme system. The subject matter also relates to use, formulation and preparation of the compounds. The compounds may be useful in the treatment of inflammatory and oxidative diseases and conditions. The compounds may also provide useful anti-proliferative and anti-apoptotic effects.

Enzyme inhibitors

The present subject matter relates generally to antioxidant compounds having the formula (I): wherein each of R, R, R, and Rare as defined below. These compounds are potentially useful as, for example, antioxidants. 

Melatonin derivatives and their use as antioxidants

Enzymatic phenoxazinone substrates of formula (I): in reaction media containing the same are used for detecting, identifying and/or quantifying microorganisms expressing at least one peptidase activity.

Enzymatic substrates derived from phenoxazinone and their use as developers in detection of microorganisms with peptidase activity

Novel enzymatic substrates of the general formula below: 

Enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity

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Sunderland, United Kingdom

Rosaleen Joy Anderson