Johns Hopkins University

Rosa V Azhari

Kam W Leong

Drew M Pardoll

Hyam I Levitsky

Elizabeth A Jaffee

Audrey Lazenby

Paul K Golumbe

Paul Golumbek

A method of stimulating a systemic immune response to a tumor cell or antigen associated with a pathogen by administering a mixture of a controlled release vehicle containing an immunopotentiating agent and antigen is described.

Controlled release of pharmaceutically active substances for immunotherapy

A method of stimulating a systemic immune response to a tumor cell or antigen associated with a pathogen by administering a mixture of a controlled release vehicle containing an immunopotentiating agent and antigen is described. The method of the invention provides sustained release of therapeutic compounds to allow a host immune system to ameliorate local as well as metastatic tumors in the host. The immunopotentiating agent is typically a cytokine such as tumor necrosis factor, GM-CSF, interleukin or interferon, for example.

Controlled release of pharmaceutically active substances for

A controlled-release pharmaceutical composition comprising a pharmaceutically active water soluble protein, peptide, glycoprotein, or mixture thereof, encapsulated in the form of microspheres by a coating of a crosslinked coacervate of gelatin and chondroitin sulfate, as well as processes for the preparation thereof.

Controlled release of pharmaceutically active substances from coacervate

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Yuvalim, Israel

Rosa V Azhari