Fundacion Centro Nacional De Investigaciones Oncologicas Carlos III

Rosa Maria Álvarez Escobar

Joaquin Pastor Fernández

Jose Ignacio Martín Hernando

Antonio Rodríguez Hergueta

Sonia Martínez González

Rosario Concepción Riesco Fagundo

Francisco Javier Ramos Lima

Ana Belén García García

David Álvaro Cebrián Muñoz

Carmen Blanco Aparicío

There is provided compounds of formula I, wherein R1, R, R, R, X, Y, Z, Rand ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds. 

Macrocyclic compounds as protein kinase inhibitors

There is provided compounds of formula (I), wherein A, A, A, A, B, B, B, B, B, B, B, Band Rhave meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. 

Inhibitors of PI3 kinase

Growing community of inventors

Madrid, Spain

Rosa Maria Álvarez Escobar