University of Texas System

University of Saskatchewan

Rosa Maldonado

Igor Almeida

Katja Michael

Carylinda Serna

Jonathan R Dimmock

Umashankar Das

Nathaniel Schocker

Miguel A Vasquez

Susana Portillo

Eva Adriana Iniguez

Rachid Skouta

Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-&#x3b1;(1,2)-R, Galp-&#x3b1;(1,3)-R, Galp-&#x3b1;(1,4)-R, or Galp-&#x3b1;(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds and therapies for treatinginfections. In certain aspects, the glycoconjugates as described herein, are incorporated into pharmaceutical compositions or vaccines

Glycoconjugate vaccine for

Certain embodiments are directed to method for synthesizing and using glycoconjugates based on the immunodominant epitope Gal&#x3b1;(1,3)Gal&#x3b2;(1,4)GlcNAc&#x3b1; (Gal&#x3b1;3LN&#x3b1;).

Glycoconjugates and methods for their use

Use of synthetic peptides derived fromantigens and their use in vaccination against trypomastigote infection and Chagas disease.uses several surface proteins to invade the host. In their role of protection, the surface protients ensure the targeting and invasion of specific cells or tissues. A conserved region in the family of mucin-associated surface proteins (MASP) was used to analyze the expression of MASP at different points of invasion and proved to be important for host cell invasion, thus suggesting MASP as a candidate for vaccine development. A synthetic peptide, MASPsyn, was studied and showed efficacy in stimulating antibody and cytokine production necessary for resistance against the parasite.

Mucin-associated surface protein as a vaccine against chagas disease

The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure relates to anti-parasitic compounds, and methods for making and for using the anti-parasitic compounds, where the anti-parasitic compounds have the general formula: where X, R, R, R, R, R, and Rare defined more fully below.

Antiparasitic compositions and methods utilizing substituted 5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-C]pyridine derivatives

Embodiments are directed to compositions and methods for treating parasitic infections. Compounds have been identified from a library of anti-cancer drugs that serve as suitable agents for targeting trypanosomatids.

Growing community of inventors

El Paso, TX, United States of America

Rosa Maldonado