Laboratorios Made, S.a.

Rosa Llobera Jimenez

Cristobal M Roldan

Juan Bosch Cartes

Fernando Rabadan Peinado

Ricardo Granados Jarque

Furfural is reacted with 2-bromo-3,4-dimethylpyridine in an ether solution of butyl-lithium at about -15.degree. C. in an inert atmosphere to form 2-furyl-(3,4-dimethyl-2-pyridyl)-carbinol, having analgesic properties.

2-Furyl-(3,4-dimethyl-2-pyridyl)-carbinol

2-Cyano-4-methylpyridine is reacted in an inert atmosphere with an ethereal solution of freshly prepared 2-furoyl-lithium followed by acid hydrolysis to form 2-(2-furoyl)-4-methylpyridine which is then reacted with methyl iodide to form 2-(2-furoyl)-1,4-dimethylpyridinium iodide. Both furoyl compounds exhibit thermal and chemical analgesic properties.

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