Duke University

Rory Henderson

Barton F Haynes

S Munir Alam

Kevin J Wiehe

The technology is directed to HIV envelopes which comprise sequence modifications wherein these modifications prevent CD4-induced transitions of the HIV envelope. Specifically, the disclosure provides recombinant HIV-1 Env proteins comprising mutations, wherein the envelope is a protomer, and wherein three protomers form a trimer stabilized by the presence of the mutations. Provided also are compositions comprising envelopes of the technology, and methods of use.

Growing community of inventors

Durham, NC, United States of America

Rory Henderson