Sanofi

Genzyme Corporation

Ronnie Wei

Gary J Nabel

Seng H Cheng

Ercole Rao

Yunxiang Zhu

Christian Lange

William Harold Brondyk

Carsten Corvey

Timothy D Connors

Christian Beil

Catherine Prades

Canwen Jiang

Zhi-Yong Yang

Lan Wu

Jochen Beninga

Edward Seung

Wulf Dirk Leuschner

Hongmei Zhao

Catherine Devaud

Yangde Chen

Leila Sevigny

Tristan Magnay

Maureen Magnay

Dietmar Hoffmann

The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Trispecific and/or trivalent binding proteins

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Needham, MA, United States of America

Ronnie Wei