William Marsh Rice University

Baylor College of Medicine

Ronke M Olabisi

Alan R Davis

Jennifer L West

Kevin Moran

Elizabeth A Davis

Christy Franco

A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new bone growth is induced by delivering cells producing BMPs from transduced viral vectors to the target cite. In various embodiments, the cells are encapsulated in hydrogel microspheres that are non-degradable or degradable by enzymes produced during the bone formation process. Various embodiments may be used to induce spinal fusion or repair critical bone defects.

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Piscataway, NJ, United States of America

Ronke M Olabisi