Omrix Biopharmaceuticals Inc.

Roni Mintz

Israel Nur

Liliana Bar

Roberto Meidler

Nadav Orr

Oleg Belyaev

Israël Nur

The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.

Immunoglobulin reduced in thrombogenic agents and preparation thereof

The invention relates to an in vitro immunoassay for quantifying thrombin in a sample comprising anti-thrombin III (AT-III) and thrombin. The method comprises the following steps: contacting the sample with a small molecule that recognizes the substrate binding site of thrombin; contacting the thrombin with a thrombin specific antibody raised against a thrombin blocked in the active site; and measuring the level of bound antibody.

Immunoassay for thrombin detection

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Moshav Shafir, Israel

Roni Mintz