Kanata Chemical Technologies Inc.

The Hong Kong Polytechnic University

Rongwei Guo

Kamaluddin Abdur-Rashid

Xuanhua Chen

Wenli Jia

Dino Amoroso

Chi-Wing Tsang

Jing Wu

Gang Chen

Todd Graham

Shuiming Lu

Albert Sun-Chi Chan

Albert S Chan

Christine Sui-Seng

The present disclosure relates to processes and methods of generating hydrogen via the dehydrocoupling of amine boranes using ligand-stabilized homogenous metal catalysts. The amine-borane is shown by the formula (I), RRN&#x2014;BHRR. A process is also shown for the preparation of a linear, branched or cyclic polymer which comprises a repeating unit of the formula (II), &#x2014;[RRN&#x2014;BRR]-n, by reacting HRRN&#x2014;BHRRin the presence of at least one ligand-stabilized metal catalyst.

Method for the production of hydrogen from the dehydrocoupling of amine boranes

The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B)) 

Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis

The present disclosure relates to a method for preparing a metal catalyst comprising at least one ligand that is coordinated to the metal through at least one phosphorous (P) atom and at least one nitrogen (N) atom, the method comprising reacting a metal pre-cursor complex with an acid addition salt of an aminophosphine, diaminophosphine, aminodiphosphine or diaminodiphosphine, in the presence of a base.

Method for preparing a metal catalyst

The present application is directed to i) a method for synthesizing aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands, ii) the use of such ligands in the preparation of metal complexes as hydrogenation catalysts, and iii) aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands of various structures. In particular, the methods in i) involve reacting a protected tertiary amine of formula (I) with a metal phosphide of the formula Y&#x2014;PR8R9 to afford an aminophosphine of formula (II), which can then be optionally further reacted with a phosphine of the formula (III) to afford the phosphine-aminophosphine of formula (IV).

Method for the preparation of aminophosphine ligands and their use in metal catalysts

The present disclosure relates to processes and methods of generating hydrogen via the hydrolysis or solvolyis of a compound of the formula (I), RRHNBHRR, using ligand-stabilized homogeneous metal catalysts.

Method for the production of hydrogen from ammonia borane

The present disclosure relates to a method for the stereoselective production of cis-4-tertbutylcyclohexanol comprising contacting 4-tert-butylcyclohexanone with hydrogen gas, a catalyst comprising a ruthenium-aminophosphine complex and a base, wherein the complex is of the formula RuX(PNH)(P)(I), wherein X is anionic ligand, (PNH) represents an aminophosphine ligand of the formula (II) RRP-L-NHand (P) represents a diphosphine ligand of the formula (III) RRP-L-PRR.

Method for the preparation of cis-4-tert-butylcyclohexanol

A process for the reduction of compounds comprising one or more carbon-oxygen (C&#x2550;0) double bonds, to provide the corresponding alcohol, comprising contacting the compound with hydrogen gas at a pressure greater than 3 atm and a catalyst comprising an iridium aminodiphosphine complex.

Iridium catalysts for catalytic hydrogenation

The present disclosure relates to a process for the hydrogenation of compounds comprising one or more carbon-oxygen (C&#x2550;O) double bonds, to provide the corresponding alcohol, comprising contacting the compound with hydrogen gas at and a catalyst comprising a ruthenium-aryl-aminophosphine complex.

Ruthenium catalysts for catalytic hydrogenation

The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.

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Mississauga, Canada

Rongwei Guo