H. Lee Moffitt Cancer Center and Research Institute, Inc.

Chongqing Zein Pharmaceutical Co., Ltd

University of Nebraska

Rongshi Li

Yan Liu

Said M Sebti

Yong Qin

Hao Song

Chunwei Cheng

Ernst Schönbrunn

Kenneth Bayles

Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.

Pyrrolomycins and methods of using the same

Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

Marinopyrrole derivatives and methods of making and using same

Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.

Inhibitors of Rho associated protein kinases (ROCK) and methods of use

Symmetrical marinopyrrole derivatives are disclosed herein, as is a synthetic route for producing these compounds. Also disclosed are methods of using symmetrical marinopyrrole derivatives to treat bacterial pathogens, like MRSE, MSSA and MRSA.

Symmetrical marinopyrrole derivatives as potential antibiotic agents

Inhibitors of rho associated protein kinases (ROCK) and methods of use

Marinopyrrole derivatives and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing cancer.

Growing community of inventors

Omaha, NE, United States of America

Rongshi Li