Other

Ip2ipo Innovations Limited

Alphacells Biotechnologies Limited

Rongjun Chen

Andrew Guy Livingston

Patrizia Marchetti

Piers Gaffney

Ruiyi Liu

Liwei Wu

Siyuan Chen

Ruijiao Dong

The present disclosure relates to the provision of novel biodegradable amphiphilic peptides and peptide analogues based derivatives comprising hydrophobic chains and their use in the permeabilization of mammalian cells and delivery of agents, for example therapeutic agents, imaging agents and cell preservation agents.

Poly(L-lysine isolphthalamide) (PLP) polymers with hydrophobic pendant chains

Processes of preparing defined monomer sequence polymers are disclosed, in which a backbone portion of the polymer is first prepared by performing one or more sequential monomeric coupling reactions with intervening membrane diafiltration purification/isolation steps, followed by a step of decorating the backbone portion with one or more side chains at predetermined positions along its length. The process represents an improvement on prior art techniques, which impose limitations on the size of the side chains that may be present. Defined monomer sequence polymers that are obtainable by the processes are also disclosed.

Defined monomer sequence polymers

Growing community of inventors

London, United Kingdom

Rongjun Chen