Beijing Biostar Technologies, Ltd.

Chengdu Biostar Pharmaceuticals, Ltd.

Other

Dalian University of Technology

Beijing Biostar Pharmaceuticals Co., Ltd.

Tang, Li

Rongguo Qiu

Li Tang

Cheng Zhang

Chuan Zhang

Jing Xu

Rixiang Kong

Recombinantfor producing de-epoxidized epothilone B by fermentation, insertional inactivation of an epoK gene in an epothilone biosynthetic gene cluster in the recombinant bacteria, and a method for producing de-epoxidized epothilone B using the recombinant bacteria.

Recombinant bacteria for producing de-epoxidized epothilone B and use thereof

The present application discloses a pharmaceutical preparation comprising a de-epoxidized epothilone derivative, and especially relates to a preparation formulation of a compound with reduced allergens and toxicity; and also relates to the use thereof in the treatment of tumours, especially the use thereof in the treatment of solid tumours that are resistant to and fail to respond to other conventional chemotherapeutic agents, as well as the use thereof in the treatment of cancers alone or in combination with other tumour drugs or auxiliary drugs.

De-epoxidized epothilone derivative preparation, preparation of same and use thereof in the treatment of tumor

Epothilone compounds represented by formula (I), their preparation methods and their use for preparing medicines are disclosed. The epothilone compounds are prepared by bioconversion and chemosynthesis or chemical modifications using epothilones or their derivatives as starting materials. Said epothilone compounds can be used to treat proliferative diseases.

Epothilone compounds, preparation method and use thereof

Novel Fostriecin (or FST) derivatives represented by formula (I), the pharmaceutical compositions and preparation methods thereof. The pharmaceutical uses of these compounds, especially the use for the preparation of pharmaceutical compositions for treating tumor, inhibiting cell over growth, or lowering myocardial infarction and the injury to cells. 

Fostriecin derivatives and the pharmaceutical uses thereof

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Beijing, China

Rongguo Qiu