Amphastar Pharmaceuticals, Inc.

Rong Zhou

Jack Yongfeng Zhang

Mary Ziping Luo

Frank Zhishi Xia

James Luo

Jianxin Gao

Denny R S Ko

A stable suspension aerosol formulation of epinephrine is suitable for administration through inhalation comprising a therapeutically effective amount of epinephrine, hydrofluorocarbon propellant, co-solvent, surfactant, and antioxidant. The suspension aerosol formulation further comprises [pre-] pre-micronized epinephrine suspended in an alcohol/surfactant solution with hydrofluoroalkane propellant. The suspension formulation provides a highly efficient delivery of drug microparticles into the respirable region of patients' lungs and has the following advantages: lower dosage requirement, minimum alcohol content, with less impurities generated during storage, improved efficacy and safety, and exhibits no ozone depleting potential compared to a formulation containing chlorofluorocarbon.

Stable epinephrine suspension formulation with high inhalation delivery efficiency

A glass bottle protective enclosure ( ) designed to protect a glass bottle ( ) in the event the bottle is subjected to an impact shock. The enclosure is provided with a leak-proof seal and is particularly adapted for protecting glass bottles ( ) containing toxic injectable medication. The enclosure ( ), which is preferably made from a transparent plastic, consists of a lower bottle container ( ) which includes a base ( ) and a plurality of shock absorbing protrusions ( ), which are located to allow a bottle label to be clearly visible, on the base ( ) is located at least one sensor cavity ( ) into which is inserted an enclosure leakage sensor ( ) consisting of either a water soluble sensor ( ) or an electronic sensor ( ). Both of which provide an indication if a bottle leakage occurs. To complete the enclosure ( ) the container ( ) includes a threaded bottle container cap ( ) which includes a plurality of cap shock absorbing protrusions ( ).

Glass bottle protective enclosure

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Fullerton, CA, United States of America

Rong Zhou