Centaurus Biopharma Co., Ltd.

Tsinghua University

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Rong Yu

Li Zhu

Yuandong Hu

Dengming Xiao

Wei Hu

Na Zhao

Yong Peng

Yongxin Han

Hong Luo

Zhi Liang

Quan Hu

Yinghui Sun

Xijie Liu

Zanping Wang

Hao-zhi Sha

Ji-zhe Cui

Xiaofeng Zhai

Shixin Wang

An electron ptychography method and an electron ptychography apparatus for automatically correcting a mistilt of a zone axis of a sample. The method includes: acquiring a diffraction pattern of each scan point of the sample by scanning the sample through using an electron beam; initializing an object function and an electron beam function, constructing a forward propagation model according to a propagation function between sample slices, and calculating a loss function to be a difference between a calculated diffraction pattern and the acquired diffraction pattern, where the calculated diffraction pattern is obtained from the forward propagation model and parameters to be optimized; calculating gradients of the loss function with respect to parameters to be optimized respectively, and optimizing the parameters to be optimized according to the gradients; executing the calculating the loss function of the forward propagation model, the calculating the gradients of the loss function with respect to the parameters to be optimized respectively, and the optimizing the parameters to be optimized according to the gradients, iteratively, till a termination condition for iterations is satisfied; and outputting the optimized parameters.

Electron ptychography method and apparatus for automatically correcting mistilt of zone axis of sample

The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and are further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provides the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans. 

Inhibitors of bruton's tyrosine kinase

The invention provides novel substituted 6-arylamino pyridone carboxamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, poly-morph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans. 

6-arylamino pyridone carboxamide as MEK inhibitors

The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions. 

Arylalkene derivatives and use thereof as selective estrogen receptor modulators

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Beijing, China

Rong Yu