Massachusetts Institute of Technology

Children's Medical Center Corporation

King Fahd University of Petroleum and Minerals

Rong Yang

Karen K Gleason

Daniel S Kohane

Lily Yun Lin

Tonio Buonassisi

Zafarullah Khan

Yaron Segal

Baby Reeja Jayan

Hafiz Zahid Shafi

The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of otitis media. Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.

Compositions with permeation enhancers for drug delivery

Disclosed are methods of preparing antifouling and chlorine-resistant coatings on reverse osmosis membranes with initiated chemical vapor deposition. The coatings enhance the stability and lifetime of membranes without sacrificing performance characteristics, such as permeability or salt retention.

Antifouling and chlorine-resistant ultrathin coatings on reverse osmosis membranes

Embodiments described herein are related to methods for processing substrates such as silicon substrates. In some cases, the method may provide the ability to passivate a silicon surface at relatively low temperatures and/or in the absence of a solvent. Methods described herein may be useful in the fabrication of a wide range of devices, including electronic devices such as photovoltaic devices, solar cells, organic light-emitting diodes, sensors, and the like.

Fabrication and passivation of silicon surfaces

Disclosed are methods of preparing antifouling coatings on reverse osmosis membranes with initiated chemical vapor deposition. The coatings enhance the stability and lifetime of membranes without sacrificing performance characteristics, such as permeability or salt retention.

Development of zwitterionic coatings that confer ultra anti-biofouling properties to commercial reverse osmosis membranes

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Cambridge, MA, United States of America

Rong Yang