National Yang Ming Chiao Tung University

Industrial Technology Research Institute

Other

Phytohealth Corporation

Acahealth Pharma & Biotech Co., Ltd.

Wu, Sophia Shu Fen

Wu, Rong-tsun

Rong-tsun Wu

Rong-Tsun Wu

Ching-Te Chang

Fen-Lan Lin

Lin-Yea Horng

Wann-Huang Liu

Kuo-Mou Chen

Kuo-Hsiung Lee

Yu Xin Zhao

Yi-Li Lee

Xiao-Ming Yang

Chien-Hsin Cheng

Hui-Ching Sung

Pei-Lun Hsu

A compound and use thereof are provided. The compound of the invention has formula I shown below. Each variable in formula I, is defined in the specification. The invention also provides a method for treating renal and cardiac dysfunction. The method includes administering to a subject in need thereof an effective amount of the compound of the invention and a pharmaceutical acceptable salt and carrier.

Medicarpin, its derivatives, manufacturing method thereof

A method for treating or preventing dry eyes is disclosed. The method comprising administering a compound to a subject in need thereof, wherein the compound is a 2,3,5,4'-tetrahydroxystilbene 2-O-&#x3b2;-D-glucopyranoside represented by the general formula (I) below, wherein R is a glucose. 

Method for treating or preventing dry eyes

Disclosed are compounds which can act as a positive allosteric modulator for erythropoietin and erythropoietin receptor and have the activity in promoting erythropoiesis. Also disclosed are pharmaceutical compositions comprising said compounds and treatment methods utilizing said compounds.

Compounds as positive allosteric modulators for erythropoietin and erythropoietin receptor to treat erythropoietin deficiency diseases

Compounds and methods for enhancing erythropoiesis. The compound contains a chemical structure of the formula (I) indicated below, in which R is a glucosyl group. In addition to having an erythropoiesis effect, the compound of the formula (I) is effective in enhancing erythropoietin formation, and increasing kidney function and expression of hepatocyte growth factor. The method includes the step of administering an effective amount of the compound of the formula (I) to a subject in need thereof and thereby results in an enhancement of erythropoiesis. 

Compounds and methods for enhancing erythropoiesis

Disclosed herein are processes for preparing extract products from the root ofThunb. and the extract products thus obtained, which are biologically active in promoting the proliferation, growth and/or differentiation of hematocytes and bone marrow cells in vitro and in vivo.

[object Object]

A method for treating a disease or disorder associated with retinal pigment epithelium (RPE) disturbance, comprising administering to a human in need thereof an effective amount of a black soybean ((L.) Merr) product is provided, wherein the black soybean product is the seed coats of black soybean or an alcoholic extract of black soybean or seed coats thereof.

Use of black soybean for treating ophthalmic diseases

Extract fractions ofsp. and methods of preparing the extract fractions are disclosed. The extract fractions enhance the proliferation and differentiation of bone marrow cells. Also described are a method for treatment of osteoporosis and a method for alleviation of side effects caused by chemotherapy by using the extract fractions ofsp.

A method for inducing mucosal immune responses in a subject in need thereof to an antigen includes administering to the subject a vaccine composition including the antigen and apolysaccharides as an adjuvant. Because of the immuomodulatory effect of thepolysaccharides, the vaccine composition is further capable of breaking immunological tolerance in the subject.

A method for treating osteoporosis in a subject in need of such treatment includes administering orally to the subject an effective amount of an extract product of aspecies capable of promoting proliferation and differentiation of bone marrow cells in the subject. Particularly, thespecies isL. cv. Phyto, characterized by a randomly amplified polymorphic DNA (RAPD) fingerprint including 14 DNA bands ranging from 428 bp, 452 bp, 537 bp, 602 bp, 723 bp, 817 bp, 934 bp, 1140 bp, 1242 bp, 1478 bp, 1641 bp, 1904 bp, 2151 bp and 2918 bp, respectively, when genomic DNA of thespecies is amplified with a primer of SEQ ID NO:9, and the extract product is prepared by a process including: (a) extracting a tuber of thespecies using an alcohol-based solvent in the presence of acetic acid; (b) subjecting the resultant product obtained in (a) to a separating treatment to obtain a soluble fraction; and (c) removing solvent from the soluble fraction obtained in (b) to extract fractions ofsp.

A substance having the following formula is provided. 

A method for treating immunological diseases and/or disorders associated with tumor necrosis factor-alpha (TNF-&#x3b1;) in a subject in need thereof is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of the coconut (Linn.) water extract or coconut (Linn.) shell extract through induction of transforming growth factor beta (TGF-&#x3b2;) or interleukin-10 (IL-10) as endogenous immunosuppressive factors.

Use of coconut water extract or coconut shell extract for treating immunological diseases and/or disorders

An extract of plantand preparing process thereof are provided. A physiologically active extract of a plantand the method thereof are provided in the present invention. The extract is obtained by an extraction of the plant or parts thereof with a water miscible organic solvent or a mixture thereof with water.

The present invention provides the composition and the method for treating autoimmune diseases and a mucosal disorder via oral-tolerance induction and innate immunity promotion. The composition for treating the autoimmune disease and mucosal disorder includes the polysaccharide prepared from a plant, wherein the plant belongs to Genus

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Taipei, Taiwan

Rong-Tsun Wu