Dionex Corporation

Rong Lin

Kannan Srinivasan

Sheetal Bhardwaj

Christopher A Pohl

Glenn Masami Kuse

Yan Liu

Zhongqing Lu

John Edward Madden

Angelo Rubero

Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes chromatogram logic to calculate the square of a retention time and a peak width variance for each of a plurality of peaks in a chromatogram; plate calculation logic to calculate an expected plate number and an observed plate number; and suppressor status logic to determine a suppressor status based on a ratio of the observed plate number to the expected plate number (O/E ratio) and to display the status.

Suppressor diagnostic tool

An electrolytic eluent generator includes an electrolyte reservoir and at least one eluent generation cartridge. The electrolyte reservoir includes a chamber containing an aqueous electrolyte solution; and a first electrode. The at least one eluent generation cartridge includes a platinum mesh electrode; a polymer screen; a plurality of reinforced membranes; a membrane washer; and a spacer including a central post and an annular projection.

Configuration for ultra high pressure electrolytic eluent generators

An electrolytic device, e.g. a suppressor, including at least two flow-through channels separated by a charged membrane barrier, and a catalyst, for combining hydrogen and oxygen gas, together with ion exchange material, disposed in one of the channels. Also, a method for simultaneous electrolysis and catalytic gas elimination in a channel of the device is described.

Gas-less electrolytic device and method

An apparatus for detecting analytes in a liquid sample may include an elongated primary channel through which an ionic species flows, the primary channel extending through a primary channel member, a first regenerant channel through which a regenerant flows, the first regenerant channel extending adjacent to the primary channel and being formed in a first block, a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block for separating the primary channel from the first regenerant channel, and a first sealing member disposed between the first charged barrier and the first block defining the first regenerant channel.

Suppressor device

An electrolytic device includes four channels separated by three charged barriers. The device can be used to suppress an eluent stream containing separated sample analyte ions and/or to pretreat a sample stream containing unseparated analyte ions.

Electrolytic four-channel device and method

An apparatus for treating an aqueous sample stream includes analyte ions. The apparatus comprises an ion exchange barrier; a sample stream flow channel; an ion receiving stream flow channel adjacent to the sample stream flow channel and separated therefrom by said first ion exchange bather. Stationary flow-through ion exchange packing is disposed in the sample flow channel of the same charge as the ion exchange bather. The ion exchange packing comprises a mixture of a first ion exchange portion with strong ionizable groups and a second ion exchange portion with weak ionizable groups of the same charge. First and second electrodes are in electrical communication with the sample stream flow channel and ion receiving flow channel.

Current-efficient suppressor and pretreatment device and method

A sandwich suppressor in an ion chromatography system in which loosely packed ion exchange resin of low density is disposed in the central sample stream flow channel. Also, a method of using the suppressor is described.

Current efficient electrolytic device and method

An electrolytic device comprising: a central sample flow channel, first and second regenerant flow channels, first and second charged barriers disposed between said sample flow channel and first and second regenerant flow channels, and pairs of oppositely charged, spaced electrodes disposed in the regenerant flow channels. Also, electrolytic devices with a different electrode configuration are described. Also, methods of using the devices, e.g., for suppression in an ion chromatography system are described.

Multielectrode electrolytic device and method

Ion chromatography apparatus including (a) a chromatographic column, (b) a source of an aqueous eluent liquid stream, (c) a detector, (d) a recycle line between the detector and the chromatographic column, and (e) a purifying device disposed along the recycle line including ion exchange removal medium. Also, such apparatus with an electrolytic purifying device disposed along the recycle line. Also, methods of using such apparatus.

Ion chromatography system with eluent recycle

The present invention provides a new design for high capacity stationary phases for chromatography, for example, ion chromatography. The stationary phases include a first polymer layer in contact with and at least partially coating the substrate of the stationary phase. The first polymer layer serves as a foundation for the attachment, and in various embodiments, the growth and attachment, of a highly hyperbranched polymer structure, typically based on one or more products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the hyperbranched polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound.

High capacity ion chromatography stationary phases and method of forming

An IC system including sample preparation. The system includes a liquid sample injection loop, an ion concentrator, an ion separator, and only a single pump for pumping fluid through the system.

IC system including sample pretreatment and using a single pump

An ion chromatography apparatus comprising: (a) a first chromatography column, (b) a second chromatography column, the volume of the second column being no greater than 0.9 times the volume of the first; and (c) valving disposed between said first and second columns permitting selective transfer of separated ionic species from first chamber to second chamber for further analysis.

Multidimensional chromatography apparatus and method

Pretreatment method and apparatus to remove matrix ions from a liquid sample, prior to separation of the sample analytes (e.g. by chromatography), by flowing the liquid sample into a sample compartment and stopping the flow. The sample compartment has a wall comprising an ion exchange membrane having exchangeable ions of the same charge as the matrix ions to be removed. A regenerant liquid stream flows through a regenerant flow compartment on the other side of the membrane from said parked liquid sample. Matrix ions in the parked liquid sample are transported across the membrane into the regenerant flow compartment. Suppression may be performed electrolytically and/or chemically. A concentrator column may also be used.

Growing community of inventors

Santa Clara, CA, United States of America

Rong Lin