International Business Machines Corporation

Peking University

Chinese Academy of Sciences

Institute of Chemistry, Chinese Academic of Sciences

Guangzhou Kangrun Biotech Co., Ltd

Rong Li

Hua Chai

Jun He

Guang Lei Li

Jie Qiao

Chuan Wei Guo

Jianjun Wang

Jie Yan

Liying Yan

Shenglin Jin

Jianyong Lv

Huiyu Xu

A serum-free cryopreservation solution contains a biomimetic ice control material, a polyol, a water-soluble sugar, and a buffer solution margin. The bionic ice control material can be polyvinyl alcohol or an amino acid compound. The cryopreservation liquid of the present invention uses the bionic ice control material as the main component, does not contain serum, has low toxicity, and can achieve a cell survival rate that is the same as, or higher than, existing cryopreservation solutions.

Serum-free cryopreservation solution and preparation method and application thereof

A cryopreservation solution contains 0.01-50.0 g of bionic ice control materials, 5.0-30 mL of polyols, 1-30 g of water-soluble sugar, and 0-30 mL of serum, and a buffer in every 100 mL of the cryopreservation solution. It does not contain DMSO. When being used for the cryopreservation of mouse oocytes and embryos, the solution may achieve the same or an even higher cell and tissue survival rate and functional expression stability as or than a commercial cryopreservation solution (containing 15% DMSO), and has high preservation efficiency. The cryopreservation solution without DMSO or serum reduces parasitic biological contaminants in the commercial cryopreservation solution containing serum currently used in clinical practice.

DMSO-free cryopreservation solution and preparation method and use thereof

A system and a method for assessing the ovarian reserve function of a subject. The system for assessing a subject's ovarian reserve function comprises: a data acquisition module configured to acquire data of the subject's age, anti-Müllerian hormone (AMH) level, follicle stimulating hormone (FSH) level, and antral follicle count (AFC); and an ovarian reserve function calculation module configured to calculate the above-mentioned information acquired in the data acquisition module, so as to work out the subject's probability of poor ovarian response (p). Further, the population is divided into four groups according to the interaction relationship between the predicted probability of poor ovarian response and the dose of ovulation stimulants, so as to divide the population with similar ovarian responses into one group.

System for the ovarian reserve function assessment of subjects

Embodiments of the inventive subject matter include receiving, in a distributed computing environment, a plurality of files for execution. Embodiments further include identifying, by parsing the plurality of files, code segments contained in each of the plurality of files. Embodiments further include determining, based on a comparison of the code segments and definitions contained in a distributed computing basic function library, a first group of the code segments that include configuration tasks and a second group of the code segments that include computational tasks. Embodiments further include combining the first group of the code segments to form a super configuration task. Embodiments further include creating an executable code, wherein the executable code comprises the super configuration task and the second group of code segments. Embodiments further include allocating the executable code to one or more nodes. Embodiments further include executing the executable code on the one or more nodes.

Framework to improve parallel job workflow

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Beijing, China

Rong Li