Snu Rdb Foundation

Jiangsu Academy of Agricultural Sciences

Jiangsu Simcere Pharmaceutical Co., Ltd

Guotai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou

Yantai Yenepharma Co., Ltd.

Rong Chen

Lei Zhang

Peng Wang

Shibao Yang

Zhixin Feng

Qiyan Xiong

Guoqing Shao

Yuan Gan

Yanfei Yu

Beibei Liu

Yun Bai

Daesub Song

Jongwoo Lim

Yao Hua

Fei Hao

Zhengping Zhang

Qingli Dong

Lulu Xu

Long Zhao

Minjoo Yeom

Wenliang Li

Yongjie Liu

Zhaolong Gong

Xing Xie

Lei Wang

Lin Feng

Fang Fang

Fulong Li

A viral vector delivery system for both respiratory and digestive tracts of pigs and an application thereof are provided. The viral vector delivery system includes a backbone plasmid and a helper plasmid. The backbone plasmid is produced by inserting a full-length cDNA of porcine enterovirus B (PEVB) into a pUC57 plasmid. The helper plasmid is produced by inserting a green fluorescent protein-coding gene into a plasmid pCAG-T7-polymerase. The viral vector delivery system can be constructed with high efficiency, can quickly cause a cytopathic effect (CPE) after infecting cells, has a viral titer up to 10TCID/mL, and can maintain high stability. A pathogenic epitope for the respiratory and digestive tracts of pigs is inserted into the backbone plasmid to produce a vaccine antigen, which is non-pathogenic, has high stability and a high viral titer, and allows a prominent immunization effect after being inoculated in pigs.

Viral vector delivery system for both respiratory and digestive tracts of pigs and application thereof

The present invention relates to the use of a composition for preparing a medicament for the treatment of amyotrophic lateral sclerosis and associated disorders. The composition comprises 3-methyl-1-phenyl-2-pyrazoline-5-one or pharmaceutically acceptable salts thereof and borneol. The medicament is a drug used for delaying the occurrence time of amyotrophic lateral sclerosis and extending the survival time, and for improving memory function defect of amyotrophic lateral sclerosis.

Use of composition for preparing a medicament for treatment of amyotrophic lateral sclerosis

Growing community of inventors

Nanjing, China

Rong Chen