Xenon Pharmaceuticals Inc.

Teva Pharmaceutical Industries Limited

Ronen Ben-David

Alexandr Jegorov

Anton Frenkel

Stephen Bierlmaier

Ralph Curtis Haltiwanger

Mehran Yazdanian

Raeann Ruiyun Wu

Daniel Levy

Yi Wang

Michael A Christie

Joseph A Sclafani

Linli He

Orel Yosef Mizrahi

Jian Chen

Harlan F Reese

Mina Gadelrab Dimitri

Graciela Noemi Gershon

Nelson G Landmesser

Partha S Mudipalli

The present invention provides solid state forms of certain spiro-oxindole compounds, such as funapide and the racemic mixture of funapide and its corresponding (R) enantiomer, pharmaceutical compositions comprising the solid state forms and processes for preparing the solid state forms and the pharmaceutical compositions.

Solid state forms of spiro-oxindole compounds

This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Asymmetric synthesis of funapide

Disclosed is crystalline R(+)-N-propargyl-1-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also disclosed is a process for the preparation of solid rasagiline base.

Process for preparing and drying solid rasagiline base

Disclosed is crystalline R(+)-N-propargyl-l-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also disclosed is a process for the preparation of solid rasagiline base.

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Netanya, Israel

Ronen Ben-David