Alltech, Inc.

Ronan Power

Thomas P. Lyons

Zi-Jian Lan

Alexandros Yiannikouris

Stefan Kwiatkowski

Thomas P Lyons

Eric Michael Ostertag

Paiman Peter Ghoroghchian

Thirupathi Reddy Yerramreddy

Clayton Matney

Casey Egan

Rijin Xiao

Jackson Colleen Lewis

Alexander Yiannikouris

Lewis Collen Jackson

Eric M Ostertag

Paiman P Ghoroghchian

Thomas Pearse Lyons

The present disclosure provides compounds of formulas (1)-(3), and compositions and methods of use thereof. The present disclosure also provides methods of preparing a provided compound and composition, and methods of characterizing a provided compound and composition.

Pharmaceutical agents, compositions, and methods relating thereto

The present application relates to compositions comprising selenium compounds, such as 5'-Methylselenoadenosine, a compound of Formula (I), and combinations thereof, and methods of using the same for inhibiting &#x3b2; amyloid aggregation, ApoE4 expression, p38 or Tau protein phosphorylation, or increasing Neprilysin and Insulin Degrading Enzyme expression.

Compositions of selenoorganic compounds and methods of use thereof

The present application relates to compositions comprising selenium compounds, such as 5'-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of formula (I), formula (II), a compound of formula (III) and combinations thereof, and methods of using the same in enhancing mitochondrial function, or treating mitochondrial dysfunction.

The present application relates to compositions comprising selenium (e.g., selenium enriched yeast) and methods of using the same to treat and inhibit obesity, diabetes and related conditions. In particular, the present application provides compositions comprising selenium enriched yeast (e.g., selenium enriched yeast comprising 2% or less inorganic selenium), and methods of using the same to enhance mitochondrial activity and function (e.g., in skeletal muscle and liver) in a subject (e.g., as a therapeutic and/or prophylactic treatment for diabetes, obesity and related conditions).

Compositions comprising selenium and use of same for the treatment and prevention of disease or conditions associated with mitochondrial dysfunction

The present application relates to compositions comprising selenium compounds, such as 5'-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of Formula (I), Formula (II), or Formula (III), and combinations thereof, and methods of using the same for modulating glucose metabolism in a subject.

The present invention relates to compositions and methods for altering cell function. In particular, the present invention provides compositions comprising selenium (e.g., SEL-PLEX) and methods of using the same (e.g., as a therapeutic and/or prophylactic treatment for neurodegenerative disease). Additionally, the present invention demonstrates that specific forms of selenium (e.g., SEL-PLEX) possess the ability to alter expression of genes associated with disease and/or aging while other forms of selenium (e.g., selenomethionine) do not.

Use of selenium compounds, especially selenium yeasts for altering cognitive function

Methods and compositions for altering cell function

Compositions comprising selenium (e.g., organic selenium (e.g., selenized yeast (e.g., SEL-PLEX))) and methods of using the same (e.g., as a therapeutic and/or prophylactic treatment) are provided. For example, compositions comprising selenium (e.g., organic selenium (e.g., selenized yeast (e.g., SEL-PLEX))) and methods of using the same are provided for treating and/or preventing one or more conditions (e.g., problems) disorders, and/or diseases related to establishing and/or maintaining a pregnancy. Compositions and methods of the invention find use in, among other things, research and clinical (e.g., preventative and therapeutic) applications.

Compositions and methods for establishing and/or maintaining pregnancy

The invention relates to soluble selenium compositions and methods of production, separation and purification thereof. In particular the present invention provides methods of preparing water soluble selenoglycoproteins (e.g., via extracting selenoglycoproteins from selenium enriched yeast), methods of supplementing a selenium deficient composition via admixing water soluble selenoglycoproteins with the selenium deficient composition, compositions comprising the water soluble selenoglycoproteins and methods of administering the same.

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Lexington, KY, United States of America

Ronan Power