University of Rochester

New York University

Novadaq Technologies Ulc

Ronald W Wood

Dragan Golijanin

Jay E Reeder

Jalil Shojaie

Edward M Messing

Hassan A El-Fawal

Lung C Chen

John F Graefe

Lukasz Brzozowski

Aimee Johnson

Paula Jaye Doyle

A surgical visualization and medical imaging device and related computer based imaging methods and systems are disclosed. The surgical devices of the present invention use indocyanine green dye combined with a plastic, and are used in enhanced surgical imaging in applications such as robotically assisted surgeries. A near infrared light source, such as an 805 nm laser, may be used to excite the surgical device so that the device emits 835 nm light. Both the excitation and emission wavelengths penetrate tissue and blood, and provide enhanced imaging of surgical procedures. The resulting fluorescence image allows a user to readily determine relative tissue depth, to identify tissue inhomogeneity, to detect masses or tissue irregularities, to pinpoint anatomical holes, and to visualize tears.

Surgical visualization and medical imaging devices and methods using near infrared fluorescent polymers

The invention provides methods for pre- and intra-operatively localizing penile sentinel lymph nodes by injection of fluorescent dyes into penile tumors.

Pre-and-intra-operative localization of penile sentinel nodes

The invention provides methods for visualizing renal tumors and for staging cysts during an operation by use of a fluorescent dye.

Intraoperative imaging of renal cortical tumors and cysts

The invention provides methods for visualizing and distinguishing sentinel lymph nodes and involved nodes from other lymph nodes in the vicinity of the bladder in patients undergoing cystectomy or other operations to remove bladder tumors.

Pre- and intra-operative imaging of bladder cancer

The present invention relates to a method for treating bladder disease, including urinary incontinence, which involves intravesical administration of quaternary antimuscarinic compounds having longer duration of effect and fewer side effects than standard treatments.

Quaternary antimuscarinic compounds for the treatment of bladder diseases

Compositions comprising antimuscarinic compounds that have been modified to render them substantially irreversible, such as by quaternization of the heterocyclic ring nitrogen, have improved properties when administered intravesically for treatment of bladder diseases, particularly urinary incontinence. Pharmaceutical compositions and methods of treatment using these improved compounds or improved routes of administration re disclosed.

Antimuscarinic compounds and methods for treatment of bladder diseases

Methylecgonidine (MEG; anhydroecgonine methylester), is produced when cocaine base ('crack') is heated. MEG alone and in combination with cocaine was tested for action on isolated tracheal rings stimulated to contact with acetylcholine. At micromolar concentrations, cocaine sensitized tracheal rings, increasing both the potency and efficacy of acetylcholine-induced contraction. Surprisingly, MEG, at nanomolar concentrations and above, non-competitively and irreversibly antagonized acetylcholine-induced contraction independently of the actions of cocaine. MEG also displayed antihistaminic activity. Therefore, MEG and anticholinergically active derivatives or analogues thereof are useful in the prevention or treatment of a disease or disorder treatable by an antimuscarinic anticholinergic agent, an anti-histaminic agent or a spasmolytic agent, in particular bronchoconstriction in a number of pulmonary diseases such as asthma.

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Nyack, NY, United States of America

Ronald W Wood