National Institutes of Health, a Component of the US Dept. of Health & Human Services

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Uniformed Services University of Health Services

Ronald W Waynant

Ilko Kolev Ilev

Kimberly Byrnes

Juanita Josephine Anders

Amir H Gandjbakhche

Ronald A Robinson

Tara B Romanczyk

Israel Gannot

Leonardo Longo

An ultrahigh-resolution fiber-optic confocal microscope has an illumination system; three single-mode optical fibers, each optically coupled to a fiber coupler; a sample support stage arranged to receive illumination radiation from an end of one of the single-mode optical fibers; a detector arranged to receive output radiation from one of the single-mode optical fibers; and a lock-in amplifier electrically connected to the detector and the illumination system. The illumination system is adapted to provide illumination radiation that has a time-varying strength that is correlated with the detector by the lock-in amplifier.

Ultrahigh-resolution fiber-optic confocal microscope and method

A method of treating spinal cord injury (SCI) includes transcutaneously irradiating at least a portion of a spinal environment of the patient with light having a power density of at least about 0.01 mW/cmat the portion of the spinal environment.

Method for treating a patient having a spinal cord injury using phototherapy

An illumination system for a particle image velocimetry system has an illumination source, a hollow tapered optical funnel arranged to receive illumination light from the illumination source, a hollow optical waveguide optically coupled to an output end of the hollow tapered optical funnel, and a beam shaping optical system optically coupled to an output end of the hollow optical waveguide. The illumination system is constructed to provide a light sheet to illuminate particles within a fluid under observation. A particle image velocimetry system has such an illumination system.

Particle image velocimetry system having an improved hollow-waveguide-based laser illumination system

Method for regeneration and functional recovery after spinal cord injury using phototherapy

The present invention relates generally to the treatment of SCI by stimulating axon regeneration within the central nerve system. One aspect of the present invention provides methods of treating SCI with low power laser irradiation (LPLI). Another aspect of the present invention provides methods of treating SCI by modulating a gene activity to stimulate axon regeneration. In this regard, the present invention also provides compositions that modulate genes expression relating to the neuron-regeneration after SCI. Another aspect of the present invention provides methods for evaluating the effectiveness of a treatment for SCI.

Light promotes regeneration and functional recovery after spinal cord injury

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Clarksville, MD, United States of America

Ronald W Waynant