Cardiac Pacemakers, Inc.

Mieczyslaw Mirowski

Other

Abbott Cardiovascular Systems, Inc.

Westlund, Randy

Heil, Ronald W., Jr.

Repasky, Christina

Bye, Lyle A.

Warren, Jay A.

Kelley, Peter T.

Scheiner, Avram

Tockman, Bruce

Soltis, Brian D.

Ronald W Heil, Jr

Avram Scheiner

Randy W Westlund

Peter T Kelley

Qingsheng Zhu

Bruce Alan Tockman

John E Heil

David M Flynn

Bruce H KenKnight

Aaron W Janke

Imad Libbus

Robert J Sweeney

Jay A Warren

Larry L Hum

Robert C Owens

Randall M Peterfeso

Roger W Dahl

Yayun Lin

Jeffrey T Bartig

Gary W Goebel

Douglas A Heitkamp

Brendan Early Koop

William Hsu

Jason Alan Shiroff

Steven D Girouard

Mary Lee Cole

Donald F Palme, Ii

Curtis Charles Lindstrom

Mudit Jain

Robert S Booker, Iii

Robert W Wickham, Jr

M Sean Coe

Rodney W Salo

Gerrard Merrill Carlson

Liliana Atanasoska

Paul E Zarembo

Mark J Bly

Jeffrey Ross

Gregory R Ley

Stuart R Chastain

Dwight A Skinner

Carol Werlein

Lyle A Bye

Mark Herner

Stephen D Pacetti

Syed F A Hossainy

Yi Zhang

Kent Lee

Anthony V Caparso

Aaron R McCabe

G Shantanu Reddy

Brian D Soltis

Paul M Consigny

Morton M Mower

Gregory M Hyde

Marina V Brockway

Douglas R Daum

Yongxing Zhang

Carlos Alberto Ricci

Dariush Davalian

Jonathan T Kwok

Darrell Orvin Wagner

Jinping Wan

Robert G Hauser

Irina Astafieva

Haris Sih

Joseph Walker

Fozan El-Nounou

Arthur L Olive

Christopher P Knapp

Jeffrey T Ellis

Shrojalkumar Desai

Daniel J Cooke

Jihong Qu

Brian D Pederson

Stanley M Bach, Jr

Katsuyuki Murase

Florian Niklas Ludwig

Matthew S Finlay

Kyle K Hoecke

Angelo Auricchio

Li Zhao

Rachel Bright

Hugo Andres Belalcazar

Harshad M Borgaonkar

Jennifer Lynn Pavlovic

Leslie J Carion

Graydon E Beatty

David B Yingling

Christina Repasky

Robert W Wickham, Jr, Deceased

Beverly Mains

J John Lattuca

Edward D Kubitschek

Wickham, Jr Robert W

By Duane Quiggle, Legal Administrator

John Kim

Haris J Sih

Bruce Tockman

A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.

Method of using a lead to regulate protein expression

The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.

Regional delivery of therapeutic agents for the treatment of vascular diseases

Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

System and method for delivering myocardial and autonomic neural stimulation

The invention relates to systems, devices, and methods for detecting infections associated with implantable medical devices. In an embodiment, the invention includes a method of detecting infection in a patient including measuring a physiological parameter using a chronically implanted sensor at a plurality of time points and evaluating the physiological parameter measurements to determine if infection is indicated. In an embodiment, the invention includes an implantable medical device including a first chronically implantable sensor configured to generate a first signal corresponding to a physiological parameter and a controller disposed within a housing, the controller configured to evaluate the first physiological parameter signal to determine if an infection is indicated. Other embodiments are also included herein.

Implantable medical device and methods for automated detection of infection

A lead having a pre-formed biased portion is adapted for implantation with a body vessel and for connection to a signal generator. The lead is constructed and arranged so that when it is implanted, the electrodes are biased toward a vessel wall by the preformed biased portion, which operates to fixate the lead against the vessel wall.

Coronary vein leads having pre-formed biased portions for fixation

An implantable lead having a distal assembly including a coupler, a fixation helix secured to the coupler, a housing in which the fixation helix and the coupler are disposed, and a resilient seal that is fixedly secured to the coupler between proximal and distal ends thereof and able to translate with the coupler relative to the housing. The seal is positioned to sealingly engage an internal surface of the housing. When the coupler is translated such that the fixation helix is in a fully extended position, the seal is positioned to substantially seal off the housing to prevent tissue ingrowth.

Extendable/retractable fixation lead with distal travelling seal and related devices

An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The plurality of zones can be tested to determine which zone delivers the best baroreflex response. At least one of the electrode zones can be selected to deliver a stimulation signal based on the testing. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.

Lead for stimulating the baroreceptors in the pulmonary artery

A medical electrical lead for transvascularly stimulating a nerve, muscle or other tissue from an adjacent vessel is described. The lead includes an expandable distal portion having one or more spirals for securing and stabilizing the lead within the vessel.

Spiral configurations for intravascular lead stability

Baroreflex stimulation system to reduce hypertension

A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

Implantable lead with flexible tip features

An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

Sensors having protective eluting coating and method therefor

An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.

Stimulation lead for stimulating the baroreceptors in the pulmonary artery

An epicardial patch includes an extracellular matrix (ECM) and a plurality of electrodes. The isolated ECM is configured for epicardial attachment over a myocardial region including an injured area to control post-injury remodeling of the myocardial region. The plurality of electrodes is configured for delivering electrical stimulation to enhance the effect of the isolated ECM in remodeling control by altering workload and stress on the myocardial region.

Epicardial patch including isolated extracellular matrix with pacing electrodes

An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.

A method includes sandblasting an electrode surface, applying a conductive oxide precursor solution to the electrode surface, and heating the electrode for at least 5 minutes at a temperature between 350 degrees C. and 550 degrees C. to convert the precursor solution into an oxide coating. One method includes applying a composite material including a conductive component and a non-conductive component to an electrode and curing the composite material to form a coating on the electrode. One method includes providing a metallic oxide coating on an electrode surface and applying a galvanostatic treatment to the electrode to increase the effective surface area of the metallic oxide coating.

Coatings for implantable electrodes

Growing community of inventors

Roseville, MN, United States of America

Ronald W Heil, Jr