Johnson Matthey Public Limited Company

Ronald Rossi

Robert Hogan

Lee Jonathan Silverberg

Ramesh M Shah

Fiona Obrock Geiser

John James Keenan

Albert Sanchez

John Michael Whelan

A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.

Method for making and storing stable cannabinoid compositions and method for treatment using such compositions

The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method.

Method for the purification of prostaglandins

Stable cannabinoid compositions and methods for making and storing them

A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be &#x394;tetrahydrocannabinol, (&#x2212;)-&#x394;-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C-Calcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.

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Composition comprising (&#x2212;)-&#x394;9-trans-tetrahydrocannabinol

A process for separating (&#x2212;)-&#x394;-trans-tetrahydrocannabinol from a mixture of cannabinoids is disclosed. The process comprises at least one chromatographic step wherein a mobile phase passes trough a stationary phase. The stationary phase comprises a derivatised polysaccharide and the mobile phase comprises carbon dioxide.

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Mullica Hill, NJ, United States of America

Ronald Rossi