Eastman-kodak Company

Research Corporation Technologies, Inc.

Ronald R Valente

Judith A Bose

Stephen P Singer

Richard F Borch

David Hoke

Louis Elbert Friedrich

Robert F Romanet

Joan C Potenza

Derek D Chapman

Dino Aimino

Gregory W Canute

Deborah D DeMejo

Photographic pyrazolotriazole dye forming coupler compounds of coupler intermediate compounds can be readily prepared in a single reaction medium by reacting certain pyrazolotriazole compounds with nitro-substituted aromatic compounds in the presence of a formate salt and a transition metal catalyst. This salt hydrogenates the nitro group and the carbonate by-product induces reaction of the resulting amine with the pyrazolotriazole compound. Yields and purity are high, and reaction time is reduced with the specific set of conditions and reactants, and environmental impact from waste is reduced. In addition, isolation of aromatic amine intermediates is avoided. The resulting pyrazolotriazole compounds can be used themselves as photographic dye forming couplers or further reacted to prepare useful coupler compounds for photographic use.

One-pot synthesis of pyrazolotriazole photographic dye forming color

Photographic pyrazolotriazole dye forming coupler compound or coupler intermediate compounds can be readily prepared by inducing an elimination-addition reaction between certain pyrazolotriazole compounds and aromatic amines in the presence of an inorganic base or formate. Yields and purity are high, and reaction time is reduced with the specific set of conditions and reactants, and environmental impact from waste is reduced. The resulting compounds can be used themselves as photographic dye forming couplers or further reacted to prepare useful coupler compounds for photographic use.

Synthesis of pyrazolotriazole photographic dye forming color couplers

The invention provides a photographic element comprising a light sensitive silver halide emulsion layer having associated therewith a dye-forming coupler having formula I: ##STR1## wherein R.sub.1 is selected from the group consisting of alkyl, aryl, and heterocyclic groups;

Photographic element containing an improved pyrozolotriazole coupler

Photographic element containing an improved pyrazolotriazole coupler

Compounds of the formula: ##STR1## which is further defined herein, possess anti-tumor activity.

Phosphoramidates useful as antitumor agents

Di-cation ether salts are prepared by a reaction sequence which comprises

Preparation of di-cation ethers

A compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 may be the same of different and are each independently hydrogen or lower alkyl which may be unsubstituted or monosubstituted with halogen, lower alkoxy or hydroxy with the proviso that the substituent is not the .alpha.-carbon or R.sup.1 and R.sup.2 taken together with the carbon to which they are attached form a morpholino ring;

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Rochester, NY, United States of America

Ronald R Valente