The University Hospital

Ronald P McCaffrey

Zachary Spigelman

Alan M Sugar

Hans L Wigzell

This invention relates to compositions comprising an adenosine derivative and a deaminase inhibitor for the prevention and treatment of fungal and fungal-like infections. Infections which are treatable and preventable with these compositions are responsible for fungal diseases such as candidiasis, cryptococcosis, blastomycosis, aspergillosis, paracoccidiodomycosis and coccidioidomycosis, and the fungal-like diseases nocardiosis and actinomycosis. The invention also relates to methods for utilizing these compositions in treatment regiments. Treatments may be either in vivo or in vitro. In vivo treatments involve administration of compositions of the invention to mammals suspected or at risk of being infected with a fungal or fungal-like organism. In vitro treatments involve incubation of cells, tissues, food products, biological products derived from living materials or foods with compositions of the invention.

Methods for the treatment and prevention of fungal infections by

The invention relates to compositions comprising an adenosine derivative and a deaminase inhibitor for the prevention and treatment of parasitic infections by eukaryotic organisms. Parasitic infections which are treatable and preventable with these compositions include malaria, trypanosomiasis, leishmania, toxoplasmosis, sarcocystis, pneumocystis, schistosomiasis, blood flukes and elephantiasis. The invention also relates to methods for utilizing these compositions in treatment regiments. Treatments may be either in vivo or in vitro. In vivo treatments involve administration of compositions of the invention to mammals suspected or at risk of being infected with a parasitic organism. In vitro treatments involve incubation of cells, tissues, biological products derived from living materials or foods with compositions of the invention to inhibit or prevent further infection.

Compositions for the treatment of parasitic infections

A therapeutic method for specifically treating terminal deoxynucleotidyl transferase-positive neoplastic disease within living subjects is provided which is uniquely effective and selective. The therapeutic method comprises administering an effective concentration of a therapeutic composition to the subject, the therapeutic composition comprising a nitrogenous heterocyclic base selected from the group consisting of purines and purine derivatives and pyrimidines and pyrimidine derivatives; and a dideoxy-pentose monosaccharide moiety.

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Needham, MA, United States of America

Ronald P McCaffrey