Chiron Corporation

University of California

Novartis Vaccines & Diagnostics, Gmbh

Northwestern University

Other

Leland Stanford Junior University

Novartis Ag

Columbia University

Sandia Corporation

Brookhaven Science Associates, Lcc

Ronald N Zuckermann

Tetsuo Uno

John E Murphy

Eric J Martin

Michael A Innis

Chin-Yi Huang

Annelise E Barron

Christoph Reinhard

Simon C Ng

Reyna J Simon

Daniel V Santi

Walter H Moos

Fred Ehrenkranz Cohen

Eric Beausoleil

Robert L Warne

Nathalie Dubois-Stringfellow

Varavani J Dwarki

Michael A Siani

Gregory Stauber

David C Spellmeyer

Cindy W Wu

Verena D Heubner

Dane A Goff

Thomas Horn

Deborah H Charych

Anne B Jefferson

Daniel J Suich

James J De Yoreo

Chun-Long Chen

Carolyn Ruth Bertozzi

Richard A Goldsmith

Brett Anthony Helms

Timothy S Burkoth

Kevin R Shoemaker

Kiet Truong

Ki Tae Nam

Kerry L Spear

Oleg Gang

Joseph L DeRisi

Michelle Dohm

George M Buffleben

David Bruce Robinson

Sally J Marshall

Barbara O Scott

Rafael Gòmez-Sjöberg

Kurt S Thorn

Ann M Czyzewski

Lutz Richter

Michael D Connolly

Rachel Ellen Gerver

Grayson W Marshall

Kuniko Saeki

David Peretz

Charles K Marlowe

Yazhong Pei

Shih-Ting Wang

Man Gao

Gulliver Timoteo

Robert M Shimizu

Tammy K Chu

Matthew Wachowicz

Srinivas Kothakota

Selina DeRose-Juarez

Matthew Geoffrey Owings

Katy Shang-Chi Kuey

Polly M Fordyce

Aaron C Sigmund

Henry Chin

Yung-Ching Chien

Tyler M Miller

Benjamin Joseph Ver Steeg

James A Patch

Brian Cullen Baxter

Nathaniel P Chongsiriwatana

Steven Banville

Rachel E Gerver

Rafael GÓMEZ-SJÖBERG

The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).

Side chain modified peptoids useful as structure-stabilizing coatings for biomaterials

Spectrally encoded microbeads and methods and devices for making and using spectrally encoded microbeads are provided. The disclosed methods and devices facilitate the preparation and use of microbeads containing multiple lanthanide nanoparticles, which microbeads have uniquely identifiable spectral codes. The disclosed microbeads, and the methods and devices for making and using same, find use in multiplexing and high-throughput biomarker analysis.

Spectrally encoded microbeads and methods and devices for making and using same

The present invention provides for a bio-mimetic polymer capable of catalyzing or mineralizing calcium ion and phosphate ions into an apatite.

Peptoids useful for the mineralization of apatite

The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.

Biomimetic peptoid polymers

The present invention provides for a bio-mimetic polymer capable of catalyzing COinto a carbonate.

Peptoids useful for catalyzing the mineralization of calcium carbonate

Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.

Cell transfecting formulations of small interfering RNA related compositions and methods of making and use

The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.

Polypeptoid pulmonary surfactants

Sequence-specific polymers are proving to be a powerful approach to assembly and manipulation of matter on the nanometer scale. Ligands that are peptoids, or sequence-specific N-functional glycine oligomers, allow precise and flexible control over the arrangement of binding groups, steric spacers, charge, and other functionality. We have synthesized short peptoids that can prevent the aggregation of gold nanoparticles in high-salt environments including divalent salt, and allow co-adsorption of a single DNA molecule. This degree of precision and versatility is likely to prove essential in bottom-up assembly of nanostructures and in biomedical applications of nanomaterials.

Materials and methods for stabilizing nanoparticles in salt solutions

Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.

Selective poly-N-substituted glycine antibiotics

The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.

Prion-specific peptoid reagents

Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule.

Fluorogenic dyes

This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.

Compositions and methods for polynucleotide delivery

Different-sequence peptoids, including lipid- and sterol-conjugated peptoids, are found to be effective in transfection of cells with oligonucleotides. Combinatorial libraries of such peptoids can be screened efficiently in a high-throughput format, and selected peptoids are identified post-screening.

Oligonucleotide transfection screening method

Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.

Peptoids incorporating chemoselective functionalities

Growing community of inventors

El Cerrito, CA, United States of America

Ronald N Zuckermann