American Home Products Corporation

Ronald N Warner

Thomas W Leonard

Atul M Mehta

Lizbeth A Bachand

Deborah M Sherman

Robin P Enever

John J Michelucci

Gerard F Thone

Kathleen L Brunelle

Richard P Weierstall

A therapeutic preparation consisting of three groups of spheroids containing an active medicinal substance. The first group of spheroids is uncoated and rapidly disintegrates upon ingestion to release an initial dose of medicinal substance a second group of spheroids is coated with a pH sensitive coat to provide a second dose and a third group of spheroids is coated with a pH independent coat to provide a third dose. A powder blend of active medicinal substance may be substituted for the first group of uncoated spheroids. The therapeutic preparation may be utilized as a mixture of groups of spheroids in a capsule.

Formulations providing three distinct releases

There are provided pharmaceutical dosage forms for oral administration comprising a gelatin capsule encapsulating an admixture of at least one solid hygroscopic medicinal substance, which would otherwise disturb the gastric tract balance, with an at least partially hydrogenated and/or solidified vegetable oil.

Formulations for hygroscopic pharmaceuticals

A calcium supplement compressed tablet containing at least about 80% by weight of tricalcium phosphate having incorporated therein as a disintegrant croscarmellose sodium and about 50% to 100% by weight based on the croscarmellose sodium of sodium lauryl sulfate.

Calcium supplement compressed tablets

Growing community of inventors

Grand Isle, VT, United States of America

Ronald N Warner