Mallinckrodt, Inc.

Mallinckrodt Medical, Inc.

Ronald M Hopkins

Mark E Bosworth

Bandula Wijayarathna

Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a diagnostic composition comprising a diagnostically effective amount of a substantially nontoxic paramagnetic image altering agent containing a chelate of a paramagnetic element such as magnesium, gadolinium or iron, carried by a liposome. The chelate is carried by or within or outside the external surface of the liposome in such a manner that after arrival at or delivery to the desired organ or tissue site, the paramagnetic image altering agent is released in a diagnostically useful fashion.

Diagnostic liposomal compositions for enhancing NMR imaging

Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a substantially nontoxic paramagnetic image altering agent comprised of a composition containing a chelate of a paramagnetic element, such as manganese, gadolinium or iron, carried by a liposome. The chelate is carried by or within the external surface of the liposome in such a manner that after arrival at or delivery to the desired organ or tissue site, the paramagnetic image altering agent is released in a diagnostically useful fashion.

Method for enhancing magnetic resonance with compositions containing

Method for enhancing magnetic resonance imaging using an image altering

An intravascular catheter, such as an angiography catheter, has a tubular body portion formed from a nylon such as nylon-11 which has strength and stiffness characteristics providing excellent torqueability, burst strength, and longitudinal rigidity. A soft tubular tip is fused to the end of the body portion to form a continuous tubular catheter. The soft tip is formed from a blend of the nylon of the body portion with an ester linked polyether-polyamide co-polymer which is soft and rubbery to render the tip soft to avoid injury to a blood vessel.

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Chesterfield, MO, United States of America

Ronald M Hopkins