Abbott Laboratories Corporation

Ronald Lee Gendrich

John Hunter Seely

Riemond Henry Rippel, Jr

William H Holleman

An endotoxin binding material affixed to a support is disclosed. One embodiment is a matrix material capable of binding endotoxins and comprising a polar, water-insoluble, high molecular weight polymer support to which is attached groups which adsorb endotoxin molecules. The groups comprise bifunctional aliphatic molecules, one end of which is bound to the support, the other end of which is bound to an aryl molecule. The invention has utility in the removal of endotoxins from biological fluids and other solutions and for concentrating endotoxins so that they may be subsequently detected and quantified.

Matrix polymers for binding endotoxins

An unnatural nonapeptide with improved biological activities surpassing those of the natural follicle-stimulating lutenizing hormone-releasing hormone (Gn--RH) is described. The new peptide induces ovulation in warm-blooded animals at an oral dose of 5-100 .mu.g./kg.

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Waukegan, IL, United States of America

Ronald Lee Gendrich