The Johns Hopkins University

Other

Ronald L Schnaar

Akira Hasegawa

Bruce Scott Bochner

Lynda J Yang

Brian E Collins

Thomas J Fralich

Yoshitak Ichikawa

The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the invention provides methods and compositions for the prevention and treatment of diseases and disorders associated with Siglec-8 expressing cells in humans, as well as other animals, through the administration of one or more novel, carbohydrate-based compounds.

Methods and compositions for treating diseases and disorders associated with siglec-8.

Methods and compositions for treating diseases and disorders associated with Siglec-8 expressing cells

The present invention is based on the identification of compounds in the form of biosynthetic precursors which can be used to modulate neuronal growth, inhibit cellular entry by pathogens and modulate immune responses. The invention further describes acylated mannosamines, and derivatives thereof, which can be used to alter the sialic acid substituents of sialoglycoconjugates.

Compounds for altering cell surface sialic acids and methods of use therefor

Compounds which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG), and a method of using the compounds for stimulating neuronal growth are provided. The invention further provides a method of identifying compounds which inhibit myelin-associated glycoprotein inhibition of axonal outgrowth of injured nerve cells. The method involves contacting the compound with myelin-associated glycoprotein under conditions which allow myelin-associated glycoprotein and the compound to bind and detecting the binding.

Compounds for stimulating nerve growth

An apparatus is provided for determining binding of mammalian cells to carbohydrates on a chromatographic plate surface. The chromatogram is performed, the plate introduced into a cell adhesion chamber, and the chamber filled with an appropriate cell containing medium. After mild centrifugation to ensure cell carbohydrates interaction, non-specific adherent cells are removed by gravitational force in the opposite direction. The plate is then carefully washed without subjecting the plate to any air/liquid interface, the cells fixed and the plate analyzed.

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Columbia, MD, United States of America

Ronald L Schnaar