Research, Incorporated

Ronald L Magolda

Kyriacos Costa Nicolaou

William E Barnette

David A Claremon

Zenon Lysenko

Stable biologically active thromboxane A.sub.2 analogues having the formula: ##STR1## wherein R.sup.1 is OR.sup.3, where R.sup.3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group; or

Method of preparing bicyclo(3.1.1)hept-2-one

Bicyclo aldehyde and process for preparation

Stable biologically active thromboxane A.sub.2 analogues having the formula ##STR1## wherein R.sup.1 is OR.sup.3, where R.sup.3 represents hydrogen or a pharmaceutically acceptable cation or lower alkyl group; or

Thromboxane A.sub.2 analogues

Stable biologically active 6,9 .alpha.-thiaprostacyclin derivatives having the formula ##STR1## wherein X represents &gt;S, &gt;SO or &gt;SO.sub.2 ;

Pharmaceutically active 6,9-thiaprostacyclin analogs and derivatives

Carbocyclic thromboxane A.sub.2 analogues

Unsaturated alcohols, thiols and thioesters are cyclized by a phenyl selenenyl halide; wherein the conformation flexibility of the unsaturated alcohol, thiol or thioester is selected such that the hydroxy group, thiol group or thioester group is capable of internal addition to at least one unsaturated bond in said alcohol, thiol or thioester; and wherein the ratio of the phenyl selenenyl halide to said unsaturated alcohol, thiol or thioester is 0.9-1.5 to 1. In a preferred embodiment, oxygen isomers and sulfur analogs of prostacyclin of the formula ##STR1## wherein X= ##STR2## Y=(E)- and (Z)- &gt;C.dbd.CH--CH.sub.2 CH.sub.2 CH.sub.2 COOR; (E)- &gt;CH--CH.dbd.CH--CH.sub.2 CH.sub.2 COOR; and

Method for preparing cyclic ethers and thioethers including oxygen

Stable biologically active aromatic prostacyclin analogues of the formula ##STR1## wherein X represents ##STR2## and R represents hydrogen, a pharmaceutically acceptable cation or a pharmaceutically acceptable lower alkyl group, are useful in the treatment of blood platelet aggregation and vascular constriction.

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Vineland, NJ, United States of America

Ronald L Magolda