The Procter Gamble Company

University of Cincinnati

Children's Hospital Medical Center

Ronald James Jandacek

Gary Robert Kelm

James C Letton

Robert A Volpenhein

Satinder Singh Bharaj

Jorge Villanueva Penafiel

Bryn Hird

Patrick Tso

Timothy B Guffey

Fred Hugh Mattson

William Randall Francis

James E Heubi

Jonathan Spinner

Disclosed are compositions, methods, and kits for treating conditions including; ameliorating side effects associated with compounds such as lipase inhibitors; gastrointestinal distress; fecal urgency; obesity; hyperlipidemia; diarrhea; reducing levels of toxic substances; reducing blood cholesterol levels; inducing satiety; effecting weight loss; effecting weight control; and treating, delaying onset and/or preventing Type II diabetes. One embodiment includes compositions for administration to an animal for stiffening lipophilic substances in the gastrointestinal tract. Such stiffening agents have a complete melting point of about 33&#xb0; C. or greater. Kits comprising the composition are also included. Methods of stiffening lipophilic substances present in the gastrointestinal tract of an animal are also provided. The methods comprise administering a composition comprising a safe and effective amount of a stiffening agent to an animal. The methods also comprise administering a composition comprising a safe and effective amount of a stiffening agent and a safe and effective amount of a lipase inhibitor to an animal.

Compositions, methods, and kits useful for the alleviation of gastrointestinal effects

The present invention is for compositions and methods for managing the body weight of a subject using said compositions. Weight management, particularly weight gain and loss, is effectuated by producing a sensation of satiety in said subjects. The method of managing body weight includes administering the composition prior to food consumption, concurrent with food consumption, as replacement for food consumption and combinations thereof.

Compositions and methods for body weight management

The use of sucrose polyester containing behenate fatty acid chains as a non-absorbable fat marker to determine total dietary fat absorption by the digestive tract of a subject. A test food for use in measuring fat absorption contains a non-absorbable fat and a dietary fat. The method is useful for diagnostic testing for diagnosing malabsorption of dietary fat by the digestive tract of the subject, and impairment of dietary fat digestion in the subject.

Use of non-absorbable fat in determining dietary fat absorption

Bread spread compositions (e.g., margarine) wherein the fat portion of the composition comprises a triglyceride oil or a non-digestible oil and a solid non-digestible sucrose polyester of a mixture of short chain and long chain saturated carboxylic acids, the molar ratio of short chain:long chain radicals being from about 4:4 to about 3:5 and the degree of esterification being from about 7 to about 8.

Improved margarine compositions/containing solid sucrose polyesters

Triglyceride cooking/salad oil compositions with fatty acid content balanced for health purposes. The fatty acid composition of the triglycerides comprises by weight:

Salad/cooking oil balanced for health benefits

Plastic shortening and other food compositions which comprise an edible oil and a fatty acid ester of sucrose wherein the fatty acid groups consist essentially of short chain fatty acid radicals containing from 2 to 10 carbon atoms and long chain fatty acid radicals containing from 20 to 24 carbon atoms in a molar ratio of short chain:long chain radicals of 5:3 to 3:5, the said esters having a degree of esterification of about 7 to 8. The edible oil can be a triglyceride oil or a nondigestible oil.

Compositions containing novel solid, nondigestible, fat-like compounds

A nutritonal fat suitable for enteral and parenteral products is disclosed. This fat consists essentially of from about 50 to 100% by weight triglycerides having the formula: ##STR1## wherein each R.sup.1 group is selected from n-heptanoyl, n-octanoyl, n-nonanoyl, n-decanoyl and n-undecanoyl groups; and the R.sup.2 groups comprise from 0 to about 90% saturated acyl groups selected from n-heptanoyl, n-octanoyl, n-nonanoyl, n-decanoyl, n-undecanoyl, lauroyl, myristoyl, palmitoyl, stearoyl and mixtures thereof; from 0 to about 90% oleoyl groups; from about 10 to 100% linoleoyl groups; and from 0 to about 10% linolenoyl groups.

Nutritional fat suitable for enteral and parenteral products

Polyol fatty acid polyesters are safe and effective agents for dissolving radiolucent gallstones when administered orally, either alone or, preferably, in conjunction with a litholytic bile acid.

Gallstone dissolution compositions and method

Non-absorbable polyol polyesters dissolve toxic lipophilic compounds in the stomach and intestine of humans and lower animals and thus decrease their absorption. The polyol polyesters also dissolve the toxic, lipophilic materials and their metabolites if they are excreted in bile, and prevent their resorption. The invention thus provides a means for detoxifying humans and lower animals which have ingested toxic lipophilic materials (e.g., DDT, Kepone, PCB, PBB) by accelerating the excretion of such materials that have accumulated in the body. The process involves oral administration to a human or lower animal in need of such treatment of a sufficient amount of a non-absorbable polyol fatty acid polyester to effect detoxification.

Detoxifying lipophilic toxins

Anti-anal leakage agents are used in combination with liquid polyol fatty acid polyesters to provide pharmaceutical and food compositions for treating and/or preventing hypercholesterolemia while avoiding undesired anal leakage of the liquid polyesters.

Compositions for treating hypercholesterolemia

Anti-anal leakage agents are used in combination with vitamin-fortified liquid fatty acid polyester compositions to provide pharmaceutical and food compositions for treating and/or preventing hypercholesterolemia while avoiding undesired anal leakage of the polyesters.

Growing community of inventors

Cincinnati, OH, United States of America

Ronald James Jandacek