The University of North Carolina at Chapel Hill

Macronex, Inc.

Ronald J Uhing

Susan L Morris-Natschke

Khalid S Ishaq

Bradley J Benson

Jose-Luis Diaz

Henry Wong

George J Cianciolo

Xiannong Chen

Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an iodo substituted nucleoside with the appropriately substituted hydroxyalkylamine.

Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, useful as

Novel N-substituted-(dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an bromoalkyl boronic acid with the purine, indole or pyrimidine base.

N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine

Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives,

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Durham, NC, United States of America

Ronald J Uhing