Taiho Pharmaceutical Company Limited

Synphar Laboratories, Inc.

Ronald J Micetich

Rajeshwar Singh

Hiroshi Matsumoto

Tomohiro Yamashita

Toshio Otani

Chan M Ha

Shinji Oie

Charles Y Fiakpui

George Thomas

Norio Unemi

Dai Q Nguyen

Shigeru Yamabe

Inder Pal Singh

Jehangir Khan

Mohsen Daneshtalab

Paul Spevak

Naobumi Ishida

Inderjit Sidhu

Bhupinder Palak

Shuichi Ueda

Takeshi Ishizawa

Mark Abel

Tetsuo Furukawa

Samuel Amedjo

Mark Tempest

Yadagiri Bathini

Sameeh Salama

A compound of formula I, or an optical isomer or pharmaceutically acceptable salt thereof, ##STR1## is disclosed as well as a pharmaceutical composition and a method of treating or preventing a fungal infection using the compound.

Triazoles as therapeutic agents for fungal infections

3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives

3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivative as

4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as antitumor agents

A high purity triazole is obtained by the reaction of a hydrazide of the general formula II and glyoxal followed by the treatment of the intermediate of general formula IV with ammonia. The total process is done in one pot and does not require the isolation of the intermediate IV. The triazole (I) is isolated by distillation. Synthesis of various N.sub.1 -substituted triazoles is also described following the same procedure.

Effective process for the production of 1,2,3-triazoles

A penicillin derivative represented by the following formula, a pharmaceutically acceptable salt thereof and an ester thereof: ##STR1## wherein n is 0, 1 or 2 and process for preparing the same.

Penicillin derivatives and process for preparation

Growing community of inventors

Sherwood Park, Canada

Ronald J Micetich