Introgene B.v.

Houghten Pharmaceuticals, Inc.

Het Nederlands Kanker Instituut

Ronald Hans Plasterk

Richard Allen Houghten

Domenico Valerio

Govert Johan Schouten

Patricia A Weber

Hendricus Gerhard Van Luenen

Jan C Vos

Ramon A Puras Lutzke

The present invention provides novel elements for improving genetic engineering techniques for producing recombinant nucleic acid molecules and/or recombinant cells. The novel elements are capable of integrating desired nucleic acid material into other nucleic acid materials, specifically into the genome of a host cell. The novel elements are derived from or based on transposons, in particular from the Tc/Mariner superfamily. In particular, the essential elements of Tc1 enabling excision and pasting of the desired nucleic acid material are provided, together with the relevant transposase activity in cis or in trans.

Vectors and methods for providing cells with additional nucleic acid

The present invention provides viral integrase inhibiting peptides having the general structure, ##STR1## where Xaa is an amino acid or an amino acid analog, the stereochemistry of the amino acids or amino acid analogs can be D-amino acids or L-amino acids and the amino and carboxy termini of the peptide can be modified. The invention also provides viral inhibiting peptides having essentially the amino acid sequence, ##STR2## The invention also provides a pharmaceutical composition comprising a viral integrase inhibiting peptide and methods of using a viral integrase inhibiting peptide in vitro or in vivo to reduce or inhibit viral integrase activity in a cell and the infectivity of a virus.

Viral integrase inhibiting peptides

Growing community of inventors

Bussum, Netherlands

Ronald Hans Plasterk