Massachusetts Institute of Technology

Ronald H Hoffeld

Antonio Sanchez-Rubio

Thomas H Jeys

Vincenzo Daneu

Nicholas M F Judson

George S Haldeman

Jonathan Z Lin

Gregory G Cappiello

Shaun R Berry

William D Herzog

Jonathan Pitts

Shane M Tysk

Amanda Goyette

A method and an apparatus of measuring a position of a particle in a flow are disclosed. An embodiment of the method comprises temporally modulating and spatially pattering an illumination beam propagating along a first dimension, passing a particle across the modulated illumination beam, detecting a temporal profile of scattered light produced by the particle's passing through the modulated illumination beam, and determining the position of the particle based, in part, on the temporal profile of the detected scattered light.

Method and apparatus for measuring a position of a particle in a flow

Aerosol and hydrosol particle detection systems without knowledge of a location and velocity of a particle passing through a volume of space, are less efficient than if knowledge of the particle location is known. An embodiment of a particle position detection system capable of determining an exact location of a particle in a fluid stream is discussed. The detection system may employ a patterned illuminating beam, such that once a particle passes through the patterned illuminating beam, a light scattering is produced. The light scattering defines a temporal profile that contains measurement information indicative of an exact particle location. However, knowledge of the exact particle location has several advantages. These advantages include correction of systematic particle measurement errors due to variability of the particle position within the sample volume, targeting of particles based on position, capture of particles based on position, reduced system energy consumption and reduced system complexity.

Particle detection systems without knowledge of a location and velocity of a particle passing through a volume of space, are less efficient than if knowledge of the particle location is known. An embodiment of a particle position detection system capable of determining an exact location of a particle in a fluid stream is discussed. The detection system may employ a patterned illuminating beam, such that once a particle passes through the various portions of the patterned illuminating beam, a light scattering is produced. The light scattering defines a temporal profile that contains measurement information indicative of an exact particle location. However, knowledge of the exact particle location has several advantages. These advantages include correction of systematic particle measurement errors due to variability of the particle position within the sample volume, targeting of particles based on position, capture of particles based on position, reduced system energy consumption and reduced system complexity.

Method and apparatus for simultaneously measuring a three dimensional position of a particle in a flow

This invention provides devices and apparatuses comprising the same, for windowless optical detection of particle-laden samples, for example aerosols or fluid suspensions. The devices make use of passive sheath flow as a mechanism for containing aerosol/fluid suspension flow. The operation of the device reduces particle loss inherent to conventional windowless optical detection schemes. Methods of optical detection and/or analysis of or the particles in a sample using devices of this invention are described.

Flow cell and methods of use thereof

Growing community of inventors

Cambridge, MA, United States of America

Ronald H Hoffeld